ORAL PHYSIOLOGY OF AGING

衰老的口腔生理学

• 批准号: 3839235
• 负责人: J A SHIP
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3839235
• 关键词: African American; age difference; aging; caucasian American; diabetes mellitus; female; gender difference; gingiva; glucose tolerance test; health surveys; human population study; human subject; longitudinal human study; male; mouth; olfactions; oral health; oral mucosa; parotid gland; periodontium; physiology; questionnaires; saliva; submandibular gland; taste; tooth loss

This project examines the status of various oral tissues during physiologic ging. The current emphasis is to study cross-sectional and longitudinal effects of ag g on oral physiology in a variety of populations: healthy whites and blacks of differ t ages, and subjects with well controlled systemic diseases. The influence of systemic isease and its treatment on aging and the oral cavity has become an important focus in ur investigations. Clinical evaluation of participants involves an oral healt questionnaire, collection of unstimulated and stimulated parotid and subman bular gland salivas, a comprehensive examination of dental, periodontal, and mucosal ti ues, an oral motor exam, and the determination of pressure, gustatory, and olfactory sen tivities. During this reporting period, results from cross-sectional studies suggest at subjects with impaired glucose tolerance and diabetes generally have similar dental, ingival, periodontal, and oral mucosal health compared to healthy controls. Cross-s tional studies reveal that smell identification diminishes with increased age, fem es have superior smell function compared to males across the life-span, and that in viduals with medical problems and taking prescription medications are more likely to be osmic. Generally healthy, community-dwelling and urban older blacks have more toot loss, greater attachment levels, and greater number of teeth with coronal restorations co ared to younger, healthy blacks. However, the general oral condition of older blac is good, perhaps due to regular general and oral health care. Results from longitud al studies in healthy individuals of different ages reveal that 5 constituents commonly f nd in stimulated parotid saliva are not diminished over a 10 year period. A ten ar longitudinal periodontal study indicates that attachment level increases ov time which is independent of age, accounted primarily by recession and not pocket dept

该项目检查了生理过程中各种口腔组织的状态 金。 的 目前的重点是研究农业的横截面和纵向效应 g口服 生理学在各种人群中：健康的白人和黑人， 年龄，以及 全身性疾病控制良好的受试者。 系统性的影响 问题和 它对衰老和口腔的治疗已成为一个重要的焦点， ur 调查事务所 参与者的临床评估涉及口腔健康 问卷调查，收集未刺激和刺激的腮腺和亚腮腺 管腺 唾液，牙齿，牙周和粘膜组织的综合检查 UEs，一个口头 运动检查，以及压力、味觉和嗅觉的测定 活动。 在本报告所述期间，横断面研究的结果表明， at受试者 葡萄糖耐量受损和糖尿病一般有类似的牙齿， 齿龈的， 牙周和口腔粘膜健康。 十字S 佐丹奴国 研究表明，气味识别随着年龄的增长而减少， es有 在整个生命周期中，与男性相比，具有上级嗅觉功能， 与...竞争 医疗问题和服用处方药更有可能是 渗透压 一般健康，社区居住和城市老年黑人有更多的嘟嘟声， 较大损失 附着体水平，以及更多的牙齿与冠状牙列， 向... 年轻健康的黑人 然而，老年黑人的一般口腔状况 是好的， 也许是由于定期的一般和口腔保健。 结果来自candidad 所有研究在 不同年龄段的健康人发现，5种成分通常存在于 日在 受刺激腮腺唾液在10年内不会减少。 十 ar 纵向牙周研究表明，附着水平增加， 的时间 是独立的年龄，主要是由经济衰退，而不是口袋部占