ORAL PHYSIOLOGY OF AGING

衰老的口腔生理学

• 批准号: 3854235
• 负责人: J A SHIP
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3854235
• 关键词: African American; Alzheimer's disease; aging; caucasian American; diabetes mellitus; health surveys; human subject; longitudinal human study; mechanical pressure; menopause; mouth; oral health; oral mucosa; parotid gland; periodontium; physiology; postmenopause; questionnaires; saliva; submandibular gland; tongue

This project examines the status of various oral tissues during physiologic aging. The current emphasis is to study cross-sectional and longitudinal effects of aging on oral physiology in a variety of populations: healthy whites and blacks of different ages, patients with Alzheimer's disease, and perimenopausal females. Healthy whites are being followed in two studies, at the Clinical Center in Bethesda, MD. and at the Baltimore Longitudinal Study of Aging (BLSA) in Baltimore, MD. Healthy, community-dwelling blacks are being studied in a collaborative study with Howard University Dental School. Perimenopausal females and patients with Alzheimer's disease are also being followed at the Clinical Center at NIH. The influence of systemic disease and its treatment on aging and the oral cavity has become an important focus in our investigations. For example, a study of the effects of glucose metabolism on oral physiology and aging is underway using the BLSA population. Clinical evaluation of healthy participants involves an oral health questionnaire, collection of unstimulated and stimulated parotid and submandibular gland salivas, a comprehensive examination of dental, periodontal, and mucosal tissues, an oral motor exam, and the determination of pressure, gustatory, and olfactory sensitivities. An additional study was initiated in the BLSA protocol utilizing an instrument designed to measure maximum tongue pressure and tongue endurance capability. During this reporting period, results from cross- sectional studies suggest that impaired glucose tolerance and diabetes have no observable effects on salivary gland function. Cross-sectional studies on unmedicated patients with Alzheimer's disease suggest that their oral health is indistinguishable from age-matched controls with the exception of specific changes in salivary gland function and gingival health. Results from longitudinal studies in healthy individuals of different ages reveal that stimulated parotid salivary gland flow rates are unchanged over 10 years.

该项目检查了各种口腔组织的状态， 生理老化 目前的重点是研究横截面和 在各种口腔生理学中， 人群：不同年龄的健康白人和黑人， 老年痴呆症和围绝经期女性。 健康的白人 随后在马里兰州贝塞斯达临床中心进行了两项研究。和 位于马里兰州巴尔的摩的巴尔的摩老龄化纵向研究（BLSA）。 健康的，居住在社区的黑人正在进行研究， 在霍华德大学牙科学院学习。 围绝经期女性， 阿尔茨海默病患者也在临床跟踪， 在NIH中心。 全身性疾病及其治疗对老年人的影响 衰老和口腔已经成为我们的一个重要焦点， 调查事务所 例如，一项关于葡萄糖代谢影响的研究 口腔生理学和衰老的研究正在进行中。 健康参与者的临床评估涉及口腔健康 问卷调查，收集未刺激和刺激的腮腺， 下颌下腺唾液，全面检查牙齿， 牙周和粘膜组织，口腔运动检查，以及 压力、味觉和嗅觉敏感性的测定。 一个 在BLSA方案中启动了额外的研究， 测量最大舌压和舌压的仪器 耐力能力。 在本报告所述期间， 部分研究表明，糖耐量受损和糖尿病 对唾液腺功能无明显影响。 横截面 对未服药的阿尔茨海默病患者的研究表明， 他们的口腔健康与年龄匹配的对照组没有区别， 唾液腺功能和牙龈的特定变化除外 健康 健康个体的纵向研究结果 不同年龄组的腮腺刺激唾液流率 10年来没有变化。