ORAL PHYSIOLOGY OF AGING

衰老的口腔生理学

• 批准号: 3875267
• 负责人: J A SHIP
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3875267
• 关键词: Alzheimer's disease; aging; health surveys; human subject; longitudinal human study; menopause; mouth; olfactions; oral mucosa; parotid gland; periodontium; physiology; postmenopause; questionnaires; submandibular gland

This project examines the status of various oral tissues during physiologic aging. The current emphasis is to study cross-sectional and longitudinal effects of aging on oral physiology in a variety of populations: healthy caucasians and blacks of different ages, and patients with dementia of the Alzheimer type. Healthy caucasians are being followed in two studies, at the Clinical Center in Bethesda, MD and at the Baltimore Longitudinal Study of Aging in Baltimore, MD. A newly initiated protocol proposes to examine healthy community dwelling blacks in a collaboration with Howard University Dental School. Additional studies on oral physiology have been initiated concerning the influence of systemic disease on aging and its impact on oral health. Clinical evaluation of volunteer participants involves an oral health questionnaire, collection of unstimulated and stimulated parotid and submandibular gland salivas, a comprehensive examination of dental, periodontal, and mucosal tissues, an oral motor exam, and the determination of pressure, gustatory, and olfactory sensitivities. During this reporting period, results from cross-sectional studies utilizing healthy subjects suggest: (1) the condition of the oral mucosa is unaffected by increasing age; (2) menopause and hormone replacement therapy have no observable effects on salivary gland function; (3) in individuals of different ages, normal oral health is supported by a wide range of salivary fluid output. Results from a group of unmedicated patients with early-stage dementia of the Alzheimer type suggest the presence of a selective impairment in submandibular gland function.

该项目检查了生理过程中各种口腔组织的状态 衰老目前的重点是研究横向和纵向 衰老对不同人群口腔生理的影响：健康 不同年龄的白种人和黑人，以及老年痴呆症患者。 老年痴呆型健康的白种人在两项研究中被跟踪， 马里兰州贝塞斯达临床中心和巴尔的摩纵向研究 位于马里兰州巴尔的摩的老龄化研究中心。一项新发起的议定书建议审查 与霍华德大学合作， 牙科学校。关于口腔生理学的其他研究已经开始 关于系统性疾病对衰老的影响及其对 口腔健康.志愿者参与者的临床评价包括口服 健康问卷，收集未刺激和刺激腮腺， 下颌下腺唾液，全面检查牙齿， 牙周和粘膜组织，口腔运动检查，以及确定 压力味觉和嗅觉的敏感性在本报告 期间，使用健康受试者的横断面研究结果 建议：（1）口腔粘膜的状况不受增加的影响 年龄;（2）绝经和激素替代治疗没有观察到 对唾液腺功能的影响;（3）在不同年龄的个体中， 正常的口腔健康由大范围的唾液分泌来支持。 结果来自一组未用药的早期痴呆患者， 阿尔茨海默型表明存在选择性损伤， 下颌下腺功能