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GLOMERULAR LESIONS IN NON-OBESE DIABETIC MICE

GLOMERULAR LESIONS IN NON-OBESE DIABETIC MICE
非肥胖糖尿病小鼠的肾小球病变
批准号：
3840305
负责人：
L J STRIKER
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3840305
关键词：
albuminuria basement membrane diabetic nephropathy disease /disorder model extracellular matrix proteins gene induction /repression insulin dependent diabetes mellitus kidney cell laboratory mouse nephrosclerosis renal glomerulus

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英文摘要
NOD mice spontaneously develop insulin-dependent diabetes mellitus (IDDM) secondary to immunologically-mediated beta cell destruction in pancreatic islets. Shortly after the appearance of diabetes, NOD mice developed renal lesions consisting of diffuse mesangial sclerosis, thickening of glomerular basement membranes, and albuminuria. These lesions closely mimic those of IDDM in humans. Morphometric analysis showed that the kidney weight and glomerular size were increased in diabetic mice, compared to non-diabetic mice, and that the ratio glomerular volume/kidney weight was elevated in diabetic mice. These findings suggest that this disproportionate increase in glomerular size may play an important role in the development of diabetic nephropathy.
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PRODUCTION OF METALLOPROTEINASES AND TIMPS BY GLOMERULAR CELLS
GLOMERULAR LESIONS IN NON-OBESE DIABETIC MICE
PRODUCTION OF METALLOPROTEINASES AND TIMPS BY GLOMERULAR CELLS
DEGRADATION OF EXTRACELLULAR MATRIX IN HUMAN GLOMERULI
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