GLOMERULAR LESIONS IN NON-OBESE DIABETIC MICE

非肥胖糖尿病小鼠的肾小球病变

• 批准号: 3840305
• 负责人: L J STRIKER
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3840305
• 关键词: albuminuria; basement membrane; diabetic nephropathy; disease /disorder model; extracellular matrix proteins; gene induction /repression; insulin dependent diabetes mellitus; kidney cell; laboratory mouse; nephrosclerosis; renal glomerulus

NOD mice spontaneously develop insulin-dependent diabetes mellitus (IDDM) secondary to immunologically-mediated beta cell destruction in pancreatic islets. Shortly after the appearance of diabetes, NOD mice developed renal lesions consisting of diffuse mesangial sclerosis, thickening of glomerular basement membranes, and albuminuria. These lesions closely mimic those of IDDM in humans. Morphometric analysis showed that the kidney weight and glomerular size were increased in diabetic mice, compared to non-diabetic mice, and that the ratio glomerular volume/kidney weight was elevated in diabetic mice. These findings suggest that this disproportionate increase in glomerular size may play an important role in the development of diabetic nephropathy.

NOD小鼠自发地发展为胰岛素依赖型糖尿病（IDDM） 继发于免疫介导的胰腺β细胞破坏 小岛 糖尿病出现后不久，NOD小鼠 肾脏病变包括弥漫性系膜硬化， 肾小球基底膜和蛋白尿。 这些病变 与人类的胰岛素依赖型糖尿病相似。 形态学分析表明， 糖尿病小鼠的肾重量和肾小球大小增加， 与非糖尿病小鼠相比， 糖尿病小鼠体重增加。 这些发现表明， 肾小球大小不成比例的增加可能在 糖尿病肾病的治疗