RENAL LESIONS IN THE ABLATION MODEL--ROLE OF GROWTH FACTORS

在大鼠中进行肾次全切除术，所谓的消融模型导致 肾脏进行性破坏，表现为慢性肾脏病 失败我们假设进行性肾小球病变是 这是由于肾小球驻留细胞更新的早期增加。这 导致肾小球异常生长，肾小球内 使用形态测量可检测的体积。我们已执行 用3H胸苷进行放射自显影，发现早在两天 在肾大部切除术后， 有丝分裂指数以及细胞形成的周转增加 动脉壁这些发现表明， 生长是肾小球硬化症发展的早期事件。

A subtotal nephrectomy in rats, the so called ablation Model leads to a progressive destruction of the kidney with manifestations of chronic renal failure. We have postulated that the progressive glomerular lesions were due to an early increase in the turnover of glomerular resident cells. This leads to an abnormal glomerular growth, with an increase in the glomerular volume detectable using morphometric measurements. We have performed autoradiographies with 3H Thymidine and found that as early as two days following the subtotal nephrectomy there was an increase in the glomerular mitotic index as well as an increase in the turnover of the cells forming the arterial wall. These findings suggest that a dysregulation of cell growth is an early event in the development of glomerulosclerosis.