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DEGRADATION OF EXTRACELLULAR MATRIX IN HUMAN GLOMERULI

DEGRADATION OF EXTRACELLULAR MATRIX IN HUMAN GLOMERULI
人肾小球细胞外基质的降解
批准号：
3840311
负责人：
L J STRIKER
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3840311
关键词：
basement membrane cellular pathology collagen complementary DNA dissection extracellular glomerulonephritis human tissue molecular pathology nephrectomy polymerase chain reaction protein degradation renal glomerulus

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中文摘要
翻译
肾小球胶原和非胶原成分的降解 细胞外基质被认为在周转中起着重要作用。 正常肾小球基底膜的表达，在肾小球疾病的发病机制中起重要作用 肾小球硬化。一种结合人体显微解剖的新方法 肾小球和竞争性聚合酶链式反应已被用于检测肾小球。 从肾切除标本中分离出来。该方法允许检测 单个肾小球中的cDNA分子，因为检测范围在 10-4个阿托莫尔的范围。肾小球分离的初步结果 从人类肾脏切除表明这种方法是敏感的， 可重复性，并允许在患者之间进行比较。
英文摘要
Degradation of collagens and non-collagenous components of the glomerular extracellular matrix is believed to play an important role in the turnover of normal glomerular basement membranes, and in the pathogenesis of glomerulosclerosis. A new method combining microdissection of human glomeruli and competitive PCR has been utilized to examine glomeruli isolated from nephrectomy specimens. This method allows the detection of cDNA molecules in individual glomeruli, because of a detection range in the range of 10-4 attomoles. Preliminary results from glomeruli isolated from human nephrectomies indicate that the method is sensitive, reproducible, and allows comparison between patients.
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