THE FUNCTION OF THE NEF PROTEIN OF SIV/MNE

SIV/MNE 的 NEF 蛋白的功能

• 批准号: 3853548
• 负责人: G FANNING-HEIDECKER
• 金额: --
• 依托单位: DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3853548
• 关键词: AIDS; X ray crystallography; diagnosis design /evaluation; gel electrophoresis; gene expression; gene induction /repression; genetic promoter element; insect virus; latent virus infection; protein structure function; serology /serodiagnosis; simian immunodeficiency virus; simian virus; transposon /insertion element; virus genetics; virus infection mechanism; virus protein

The function of the Nef protein encoded by HIV and simian immunodeficiency virus (SIV) is still unknown. Several reports propose that they are involved in viral latency due to a negative effect on viral transcription. Frequent inactivating mutations in the gene occurring during virus isolation suggest that the gene is not tolerated well during propagation in tissue culture. In order to investigate the function of this gene we have extended our screen of animals infected with different isolates of SIV to see whether the appearance of the anti-nef response has a prognostic value for disease progression as has been reported in the case of HIV and human AIDS.

HIV和猿猴编码的Nef蛋白的功能