VIRUS INFECTIONS IN THE EYE

我们研究了各种病毒学和免疫病理过程 当病毒在眼睛微环境中复制时。这个项目 包括三个方面：(1)冠状病毒感染眼部和眼部的研究 视神经细胞；(2)病毒在 人类疾病；(3)抗病毒治疗作用的研究 细胞因子和药物。 我们已经证实，小鼠冠状病毒可以诱发眼部疾病和 可作为研究视网膜退行性疾病的模型系统。 这款车有很多独特的特点。该病毒能够诱导一种 急性感染伴轻度炎症。初始视网膜 损害之后是病毒的清除和进行性视网膜 破坏，甚至在病毒消失几个月后也是如此。除了……之外 形态损伤，病毒会导致重新分布和减少 光感受器间视黄醇结合蛋白(IRBP)。这些结果 证明该病毒可引起生化和形态变化 在检测到病毒后很长一段时间内持续并进展的视网膜中。 本病可作为退行性疾病的一种模型。 人类的色素上皮和光感受器。 需要有效的药物治疗和预防疱疹病毒和 其他病毒性疾病也变得越来越重要。我们发现 白细胞调节蛋白是一种自然产生的免疫细胞因子，它增加了 药物阿昔洛韦的抗病毒作用。我们的发现表明 免疫疗法和化疗相结合可以产生大量的 抑制疱疹病毒复制，为 这种方法在病毒感染治疗中的应用。

We have studied various virologic and immunopathologic processes that occur when viruses replicate in the ocular microenvironment. This project consists of three areas: (1) studies on coronavirus infection in ocular and optic nerve cells; (2) determination of the possible roles of viruses in human diseases; and (3) studies on antiviral therapeutic actions of cytokines and drugs. We have established that murine coronavirus can induce ocular disease and may be used as a model system for studying retinal degenerative diseases. This model has many unique features. The virus is capable of inducing an acute infection in the presence of mild inflammation. The initial retinal damage is followed by clearance of the virus and progressive retinal destruction, even months after the virus is gone. In addition to morphologic damage, the virus causes a redistribution and reduction in interphotoreceptor retinoid-binding protein (IRBP). These results demonstrate that the virus can induce biochemical and morphological changes in the retina that persist and progress long after the virus is detectable. This disease may be considered a model for degenerative diseases of the pigment epithelium and photoreceptors in humans. The need for effective drug treatment and prevention of herpes virus and other viral diseases has assumed growing importance. We found that leukoregulin, a naturally occurring immunologic cytokine, increases the antiviral actions of the drug acyclovir. Our findings, which demonstrate that combination immunotherapy and chemotherapy can produce substantial inhibition of herpesvirus replication, provide a rationale for the application of this approach to the treatment of virus infections.