TOXOPLASMOSIS INFECTIONS IN THE EYE

弓形虫感染是视力丧失和失明的主要原因 眼弓形虫病可能是先天性感染的结果， 感染，并作为免疫抑制的表现，特别是作为 移植或获得性免疫缺陷综合征（AIDS）的结果。 由于最近巴西获得性眼弓形虫病的死灰复燃， 艾滋病毒感染中弓形虫病的全球并发症，我们开始 研究开发获得性弓形虫病模型，以评估 发病的分子机制和治疗策略。 我们已经建立了一种眼部弓形虫病的小鼠模型， 其特征在于视网膜炎症、脉络膜视网膜瘢痕、视网膜 组织解体和囊肿形成。视网膜疾病发生在三个不同的 不 小鼠皮下接种弓形虫病后， 或腹膜内途径。 该获得性眼弓形虫病模型是 用于评价新的抗寄生虫药物在控制 G 视网膜囊肿形成和视网膜炎症的发展。

Toxoplasma gondii infections are a major source of visual loss and blindnes Ocular toxoplasmosis may occur as a result of congenital infections, acquir infections, and as a manifestation of immunosuppression, particularly as a result of transplantation or acquired immunodeficiency syndrome (AIDS). Due to the recent resurgence of acquired ocular toxoplasmosis in Brazil and the worldwide complications of toxoplasmosis in HIV infections, we initiate studies to develop a model of acquired toxoplasmosis to evaluate the molecular mechanisms of pathogenesis and therapeutic strategies. We have developed a murine model of ocular toxoplasmosis that is characterized by retinal inflammation, chorioretinal scaring, retinal disorganization, and cyst formation. Retinal disease occurs in three differ t strains of mice following inoculation with toxoplasmosis by the subcutaneou or intraperitoneal routes. This model of acquired ocular toxoplasmosis is being used to evaluate the efficacy of new antiparasitic agents in controll g the development of retinal cyst formation and retinal inflammation.