VIROLOGIC AND IMMUNOPATHOLOGIC ASPECTS OF EYE DISEASES

眼科疾病的病毒学和免疫病理学方面正在研究， 视觉和眼部疾病中免疫调节系统的鉴定 并通过评估病毒在病因学中的参与， 眼科疾病的发病机制。 疾病中的调节机制正在通过集中研究 淋巴因子（干扰素（IFN）、白细胞介素2）、细胞因子（IL-2）、细胞因子（IFN-γ）、细胞因子（IL-10）、细胞因子（IL-10）、细胞因子（IL-10）之间的相互作用 表面蛋白（HLA-DR，Ia）和眼内的选定细胞（视网膜 色素上皮（RPE）细胞、光感受器、内皮细胞）。 这些 研究已经确定了IFN系统和II类抗原的改变 在视网膜变性、炎性眼病和选定的 免疫介导的疾病（获得性免疫缺陷综合征 （AIDS）、自身免疫）。 目前正在研究开发单克隆抗体， 视网膜细胞（RPE）的识别。 由于RPE细胞是一种 视网膜中重要的调节细胞， 淋巴因子、II类抗原和RPE细胞功能正在评估中。 病毒在人类眼病病因和发病机制中的作用 动物正在被研究。 试图在组织中识别病毒， 葡萄膜炎和急性视网膜坏死的患者正在进行中。

Virologic and immunopathologic aspects of eye diseases are being studied by the identification of immunoregulatory systems in vision and ocular disease and by the evaluation of the involvement of viruses in the etiology and pathogenesis of eye diseases. Regulatory mechanisms in disease are being investigated by concentrating on the interactions among lymphokines (interferon (IFN), interleukin 2), cell surface proteins (HLA-DR, Ia) and selected cells within the eye (retinal pigment epithelial (RPE) cell, photoreceptors, endothelial cells). These studies have identified alterations in the IFN system and class II antigens in retinal degenerations, inflammatory eye diseases and in selected immunologically mediated diseases (Acquired Immunodeficiency Syndrome (AIDS), autoimmunity). Studies are in progress to develop monoclonal antibodies to identify retinal cells (RPE). Since the RPE cell is an important regulatory cell in the retina, the interactions among lymphokines, class II antigens and RPE cell function are being evaluated. The role of viruses in the etiology and pathogenesis of eye diseases in man and animals is being studied. Attempts to identify viruses in tissues from patients with uveitis and acute retinal necrosis are in progress.