CHARACTERIZATION OF IMMUNE RESPONSES TO S-ANTIGEN

实验性自身免疫性葡萄膜炎(EAU)是由 通过注射各种可溶性视网膜获得遗传易感动物 佐剂中的抗原。这些抗原中最具特性的是S抗原。这个 它引起的葡萄膜炎严重依赖于活化T细胞的存在 细胞。已经证实，T细胞被激活是由于 它们与启动的抗原提呈细胞的相互作用，通过 包涵体蛋白被内化并部分消化。 然后，原始蛋白质的片段在细胞上重新表达 它们可以与T细胞相互作用的表面。正在进行的工作是 识别和表征那些导致 在动物和人类中的临床反应。

Experimental autoimmune uveitis (EAU) is a disease model induced in genetically susceptible animals by injection of various soluble retinal antigens in adjuvant. The best characterized of these antigens is S-Ag. The uveitis it induces is critically dependent on the presence of activated T cells. It has been established that T cells become activated as a result of their interaction with primed antigen-presenting cells, a process through which the enciting protein is internalized and partially digested. Fragments from the original protein are then reexpressed on the cell surface where they can interact with T cells. Work is being carried out to identify and characterize those fragments which are responsible for the clinical response in animals as well as in humans.