CHARACTERIZATION OF IMMUNE RESPONSES TO RETINAL SPECIFIC ANTIGENS

S抗原(S抗原)和光感受器的特性之一 视黄醇结合蛋白(IRBP)是视网膜特异的抗原， 当在佐剂存在的情况下注射时，它们的能力 在实验性眼部诱发强烈的自身免疫性炎症 动物。这种疾病被称为实验性自身免疫性葡萄膜炎(EAU)， 严重依赖于T细胞和抗原的处理 抗原提呈细胞(APC)。加工外源的第一步 抗原是通过胞饮作用或胞饮作用将其内化为APC 吞噬作用。抗原的处理或分解发生在 酸性内吞囊泡，导致小泡的生成 多肽。一旦产生，这些小的多肽必须是 防止进一步退化并被运送到后高尔基时代 复合体，在那里它们可以与II类抗原结合。这是感觉到的 热休克蛋白(HSP)可能在这两种疾病中起重要作用 流程。

One of the characteristics of S-Antigen (S-Ag) and interphotoreceptor retinoid-binding protein (IRBP), which are retinal-specific antigens, is their ability, when injected in the presence of an adjuvant, to induce an intense autoimmune inflammation in the eyes of experimental animals. This disease, called experimental autoimmune uveitis (EAU), is critically dependent on T cells and antigen processing by antigen-presenting cells (APC). The first step in processing exogenous antigens is their internalization into an APC by pinocytosis or phagocytosis. Processing or breakdown of the antigen occurs within acidic endocytic vesicles, resulting in the generation of small polypeptides. Once generated, these small polypeptides must be protected from further degradation and transported to the post-Golgi complex, where they can associate with class II antigens. It is felt that heat shock proteins (hsp) may play an important role in both processes.