AIRWAYS HYPERRESPONSIVENESS IN MICROVASCULAR ANGINA

微血管心绞痛中的气道高反应性

• 批准号: 3858118
• 负责人: R CANNON
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3858118
• 关键词: angina pectoris; angiography; blood flow measurement; bronchioles; cardiovascular disorder diagnosis; coronary artery; dyspneas; heart circulation; heart disorder diagnosis; human subject; methacholine; microcirculation; muscle stress; myocardial ischemia /hypoxia; respiratory airflow measurement; respiratory airway pressure; vascular smooth muscle

Chest pain in patients with angiographically normal coronary arteries may be caused by a limited coronary flow response to stress because of abnormal function of the coronary microcirculation (microvascular angina). Because dyspnea is common in these patients and seems disproportionate to the severity of myocardial ischemia, we studied airflow in the basal state and after methacholine inhalation to determine whether bronchial smooth muscle is affected in this syndrome. Nineteen of 35 patients (53%) with microvascular angina had abnormal resting or methacholine-provoked airflow responses, a significantly greater prevalence of abnormal airflow studies compared to 9 patients with heart disease (O%, p>0.025) and 24 normal volunteers of similar age and gender distribution (13%, p>0.025). Furthermore, the product of the methacholine dose inhaled and the magnitude of decline in forced expiratory volume in one second (FEVI) from baseline was significantly lower in patients with microvascular angina than in normal volunteers. We conclude that airway hyporesponsiveness is frequently demonstrable in patients with microvascular angina; these findings are consistent with the hypothesis that this syndrome may represent a more generalized abnormality of vascular and nonvascular smooth muscle function.

冠状动脉造影正常的患者胸痛可能 是由有限的冠状动脉血流对压力的反应引起的， 冠状动脉微循环（微血管）功能异常 心绞痛）。 因为呼吸困难在这些患者中很常见， 与心肌缺血的严重程度不成比例， 在基础状态和乙酰甲胆碱吸入后的气流，以确定 支气管平滑肌是否受到影响。 十九 35例微血管性心绞痛患者（53%）有异常静息或 乙酰甲胆碱引起的气流反应， 与9例心脏病患者相比，异常气流研究的患病率 24例年龄和性别相近的正常志愿者 分布（13%，p>0.025）。此外，乙酰甲胆碱的产物 吸入剂量和用力呼气量下降的幅度 与基线相比， 微血管性心绞痛的发病率高于正常志愿者。 我们得出结论， 低反应性常表现为 微血管性心绞痛;这些发现与假设一致 这种综合征可能代表了一种更普遍的异常， 血管和非血管平滑肌功能。