Defining the genes that dictate the cellular response to tumour protein TP53 activation

定义决定细胞对肿瘤蛋白 TP53 激活反应的基因

• 批准号: nhmrc : 2001201
• 金额: $ 78.49万
• 依托单位国家: 澳大利亚
• 项目类别: Ideas Grants
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/defining-genes-dictate-tp53-activation/1779723
• 关键词: Defining; genes; dictate; cellular; response

The tumour suppressor TP53 prevents the growth of abnormal cells by activating processes such as cell death and irreversible growth arrest. A cell will undergo only one of these possible responses, but it is not known why some cells die and others only stop growing. We will use innovative methods to define the genes that dictate the cellular response to TP53 activation. This research has implications for cancer, as many therapeutics aim to permanently kill cancer cells by activating TP53.

肿瘤抑制因子TP53通过激活细胞死亡和不可逆生长停滞等过程来防止异常细胞的生长。一个细胞只会经历这些可能的反应之一，但目前还不知道为什么有些细胞会死亡，而另一些细胞只会停止生长。我们将使用创新的方法来定义决定细胞对TP53激活反应的基因。这项研究对癌症有意义，因为许多治疗方法的目标是通过激活TP53永久杀死癌细胞。