Defining the function of the thrombin receptor, PAR4, on human platelets

定义人类血小板上凝血酶受体 PAR4 的功能

• 批准号: nhmrc : 1047295
• 负责人: A/Pr Justin Hamilton
• 金额: $ 36.1万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/defining-function-thrombin-human-platelets/111927
• 关键词: Defining; function; thrombin; receptor; PAR4

Inappropriate blood clot formation is the cause of most heart attacks and strokes, and platelets are the cells in the blood which form these clots. Drugs that block platelet function, such as aspirin, are used to prevent heart attack and stroke but are frequently ineffective. We will study the signals which control platelet incorporation into clots in order to discover improved therapeutic strategies for heart attack and stroke prevention.

不适当的血块形成是大多数心脏病发作和中风的原因，血小板是血液中形成这些血块的细胞。阻断血小板功能的药物，如阿司匹林，被用来预防心脏病发作和中风，但往往无效。我们将研究控制血小板并入血栓的信号，以发现改善心脏病发作和中风预防的治疗策略。