Defining the roles of platelet protease-activated receptors in thrombosis

定义血小板蛋白酶激活受体在血栓形成中的作用

• 批准号: nhmrc : 491143
• 负责人: A/Pr Justin Hamilton
• 金额: $ 22.05万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/defining-roles-platelet-receptors-thrombosis/83033
• 关键词: Defining; roles; platelet; protease; activated

Inappropriate blood clot formation is the cause of most heart attacks and some strokes. Platelets are the blood cells responsible for such clots. We are interested in the signals which control platelet incorporation into clots because drugs that interfere with this may be effective at inhibiting unwanted clot formation. Our studies determining the importance of platelet signals will provide strong clues to the likely effectiveness of blocking such signals as anti-clotting agents.

不适当的血凝块形成是大多数心脏病发作和一些中风的原因。血小板是造成这种血块的血细胞。我们对控制血小板并入血块的信号很感兴趣，因为干扰这种信号的药物可能有效地抑制不想要的血块形成。我们的研究确定了血小板信号的重要性，将为阻断这些信号作为抗凝血剂的可能有效性提供强有力的线索。