INFECTION OF RABBITS WITH HUMAN IMMUNODEFICIENCY VIRUS 1

兔注射感染人T细胞系的实验研究 HIV-1在注射后4周内引起血清转换。正常情况下，5X10 给药6个细胞。如果使用更高剂量，血清转换率 发病较早，抗体水平升高。 已有130只兔子成功感染。五 在最初的剂量后，有百分比的动物没有血清转换。 受感染的细胞，但在加强免疫后可检测到抗体 注射。已通过聚合酶链式反应检测到该病毒 病毒DNA和RNA在脑和淋巴组织中的扩增。 对破伤风类毒素和卡介苗的免疫反应已经在 被感染的动物，并被证明是减少或不存在。

Injection of rabbits with human T-cell line that has been infected with HIV-1 causes seroconversion within 4 weeks of injection. Normally, 5 X 10 6 cells are administered. If higher doses are used, the seroconversion occurs earlier and the levels of antibody are elevated. One hundred and thirty rabbits have been successfully infected. Five percent of the animals did not seroconvert after the original dose of infected cells, but antibody could be detected following a booster injection. The virus has been detected by polymerase chain reaction amplification of viral DNA and RNA in brain as well as lymphoid tissues. Immune responses to tetanus toxoid and to BCG have been monitored in infected animals and were shown to be diminished or absent.