INFECTION OF RABBITS WITH HUMAN IMMUNODEFICIENCY VIRUS 1

给兔子注射已经感染了6个 HIV-1在注射后4周内引起血清转化。通常，5 x 如果使用更高剂量，则血清转化 发生得更早，抗体水平也会升高。 130只兔子被成功感染。五 %的动物在初始剂量后未发生血清转化 感染的细胞，但抗体可以通过以下加强检测 注射已通过聚合酶链反应检测到病毒 脑和淋巴组织中病毒DNA和RNA的扩增。 对破伤风类毒素和卡介苗的免疫反应已在2000年进行了监测， 感染的动物，并显示减少或不存在。

Injection of rabbits with a human T-cell line that has been infected 6 with HIV-1 causes seroconversion within 4 weeks of injection. Normally, 5 x 10(6) cells are administered, if higher doses are used, the seroconversion occurs earlier and the levels of antibody are elevated. One hundred and thirty rabbits have been successfully infected. Five percent of the animals did not seroconvert after the original dose of infected cells, but antibody could be detected by following a booster injection. Virus has been detected by polymerase chain reaction amplification of viral DNA and RNA in brain as well as lymphoid tissues. Immune responses to tetanus toxoid and to BCG have been monitored in infected animals and were shown to be diminished or absent.