NEUROIMMUNOLOGY AND MOLECULAR BIOLOGY OF SCHIZOPHRENIA

精神分裂症的神经免疫学和分子生物学

• 批准号: 5203824
• 负责人: H KULAGA
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5203824
• 关键词: Retroviridae; autoantibody; cell population study; cerebrospinal fluid; human subject; human tissue; immunopathology; interview; latent virus infection; lymphocyte; nervous system infection; neuroimmunomodulation; neurotropic virus; polymerase chain reaction; postmortem; schizophrenia; tissue /cell culture; virus DNA

This neurovirology and neuroimmunology project focuses on obtaining evidence that the pathogenesis of schizophrenia and other neuropsychiatric illnesses may be an infectious process, involving either a viral agent and/or an autoimmune reaction involving central nervous system tissue autoantibodies. The techniques used involve the quantification of specific proteins, including immunoglobulins, in the cerebrospinal fluid (CSF), stimulation of cultured lymphocytes in order to identify latent retroviral infection, the use of the polymerase chain reaction (PCR) in an effort to identify small quantities of viral genomic DNA in postmortem brain tissue, and the assessment of lymphocyte subpopulations.

这个神经病毒学和神经免疫学项目的重点是获得 有证据表明精神分裂症和其他 神经精神疾病可能是一种感染性过程，涉及 病毒因子和/或涉及中枢神经系统的自身免疫反应 系统组织自身抗体。 所使用的技术涉及 定量的特定蛋白质，包括免疫球蛋白，在 脑脊液（CSF），刺激培养的淋巴细胞， 为了识别潜伏的逆转录病毒感染，使用聚合酶链， PCR反应（PCR），以识别少量的病毒基因组 死后脑组织DNA及淋巴细胞计数 亚群