精神分裂症的神经免疫学和分子生物学-猫眼课题宝

精神分裂症的神经免疫学和分子生物学

批准号：

5203824

负责人：

H KULAGA

金额：

$0.0万

依托单位：

NATIONAL INSTITUTE OF MENTAL HEALTH

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/5203824

关键词：

Retroviridae autoantibody cell population study cerebrospinal fluid human subject human tissue immunopathology interview latent virus infection lymphocyte nervous system infection neuroimmunomodulation neurotropic virus polymerase chain reaction postmortem schizophrenia tissue /cell culture virus DNA

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英文摘要

This neurovirology and neuroimmunology project focuses on obtaining evidence that the pathogenesis of schizophrenia and other neuropsychiatric illnesses may be an infectious process, involving either a viral agent and/or an autoimmune reaction involving central nervous system tissue autoantibodies. The techniques used involve the quantification of specific proteins, including immunoglobulins, in the cerebrospinal fluid (CSF), stimulation of cultured lymphocytes in order to identify latent retroviral infection, the use of the polymerase chain reaction (PCR) in an effort to identify small quantities of viral genomic DNA in postmortem brain tissue, and the assessment of lymphocyte subpopulations.

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