KINETIC MODELING OF TISSUE HETEROGENEITY IN METABOLISM AND BLOOD FLOW STUDIES

代谢和血流研究中组织异质性的动力学建模

• 批准号: 3860016
• 负责人: K SCHMIDT
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3860016
• 关键词: antipyrine; brain metabolism; computer simulation; deoxyglucose; glucose metabolism; mathematical model; model design /development; positron emission tomography; radiotracer

Adaptations of the [14C]deoxyglucose method for the quantitative determination of local rates of cerebral glucose consumption and of the [14C]iodoantipyrine method for determination of local rates of cerebral blood flow for human use with PET and [18F]fluorodeoxyglucose and 15 O- labeled water, respectively, have presented some special problems. Due to the limited spatial resolution and partial volume effects of PET scanners, measurement of radioactivity in homogeneous tissues is rarely, if ever, achieved. Hence one of the explicit assumptions of both methods, that of tissue homogeneity, is not met; this assumption is frequently forgotten or ignored, and serious misinterpretations and misuses of the methods have resulted. We have examined the effects of tissue heterogeneity on determinations of local cerebral blood flow and glucose utilization and have developed mathematical models to explicitly account for the tissue heterogeneity. These models have been validated in simulation studies and are currently being validated in human and animal studies. In addition, we are assessing the special time constraints for the use of [18F]fluorodeoxyglucose with PET in man. The results of these studies will provide us with the necessary information for choosing the most appropriate kinetic models and optimal experimental protocols for the measurement of glucose utilization and blood flow with PET.

[14 C]脱氧葡萄糖方法的改进 测定局部脑葡萄糖消耗率， [14 C]碘安替比林法测定脑局部放射性 使用PET和[18 F]氟脱氧葡萄糖和15 O- 标记的水，分别提出了一些特殊的问题。 由于 PET扫描仪有限的空间分辨率和部分体积效应， 在同质组织中的放射性测量很少，如果有的话， 办妥了一批 因此，这两种方法的明确假设之一是， 组织同质性不符合;这个假设经常被遗忘，或者 忽视，严重的误解和误用的方法， 结果。 我们已经研究了组织异质性对 局部脑血流量和葡萄糖利用的测定， 已经建立了数学模型来明确地解释 异质性 这些模型已在模拟研究中得到验证， 目前正在人类和动物研究中得到验证。 另外我们 正在评估使用 [18F]氟脱氧葡萄糖与PET在人。这些研究的结果将 为我们提供必要的信息，以选择最合适的 动力学模型和最佳实验方案的测量 葡萄糖利用率和血流量。