TREATMENT OF PRECOCIOUS PUBERTY WITH LEUPROLIDE ACETATE

用醋酸亮丙瑞林治疗性早熟

• 批准号: 3863946
• 负责人: RAPHAEL R DAVID
• 金额: --
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3863946
• 关键词: adrenal disorder; child (0-11); clinical trials; female reproductive system disorder diagnosis; follicle stimulating hormone; gonad disorder; gonadotropin releasing factor; hormone regulation /control mechanism; human subject; leuprolide; luteinizing hormone; male reproductive system disorder diagnosis; precocious puberty

Patients will be screened to distinguish those with central precocious puberty and those with pseudosexual precocity due to adrenal or gonadal disease. Those patients found to have central precocious puberty will undergo a modified gonadotropin-releasing hormone (GnRH) test with acqueous leuprolide acetate, a GnRH antagonist, and serial bloods will be drawn for LH and FSH over the subsequent 24 hours. A long-acting form of leuprolide acetate will then be administered intramuscularly on a monthly basis for six months.

将对患者进行筛查，以区分中枢性早熟患者 青春期和那些由于肾上腺或性腺的假性性早熟 疾病那些被发现患有中枢性性早熟的患者将 接受改良的促性腺激素释放激素（GnRH）试验， 醋酸亮丙瑞林（一种GnRH拮抗剂）和连续采血， LH和FSH在随后的24小时内。一种长效亮丙瑞林 然后每月肌肉注射醋酸盐， 六个月