Defining the mechanisms regulating tissue mechano-reciprocity in wound healing

定义伤口愈合中组织机械相互作用的调节机制

• 批准号: nhmrc : GNT1103713
• 负责人: A/Pr Michael Samuel
• 金额: $ 62.45万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/defining-mechanisms-regulating-wound-healing/1346299
• 关键词: Defining; mechanisms; regulating; tissue; mechano

Wound healing is slow in people with diseases including diabetes or reduced blood circulation to the limbs. Wounds that remain unhealed for a long time may require surgery and limb amputations, often leading to disability and premature death, while costing the health system $3 billion/yr. We have found that wound healing can be accelerated more than 2-fold by the inhibition of a protein called 14-3-3zeta, and seek to find out how this occurs so that it may be exploited for therapy.

患有糖尿病或四肢血液循环减少等疾病的人伤口愈合缓慢。长期未愈合的伤口可能需要手术和截肢，往往导致残疾和过早死亡，同时每年给卫生系统造成30亿美元的损失。我们发现，通过抑制一种名为14-3-3 -3zeta的蛋白质，伤口愈合速度可以加快两倍以上，并试图找出这是如何发生的，以便将其用于治疗。