Elucidating the function of Rho-ROCK signalling in the regulation of cancer progression

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As cancers progress from benign to more malignant forms, the way in which cancer cells respond to external influences changes dramatically. These cells subvert the normal interactions between proteins which pass signals from outside the cell to the inside, to control cell behaviour and assume a survival advantage. We plan to study a form of cell signalling that is often abnormal in cancer in order to identify technologies for limiting cancer growth and spread by interfering with these signals.