Elucidating the function of Rho-ROCK signalling in the regulation of cancer progression

阐明 Rho-ROCK 信号在癌症进展调节中的功能

• 批准号: nhmrc : 1021323
• 负责人: A/Pr Michael Samuel
• 金额: $ 42.45万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/elucidating-function-rho-cancer-progression/110110
• 关键词: Elucidating; function; Rho; ROCK; signalling

As cancers progress from benign to more malignant forms, the way in which cancer cells respond to external influences changes dramatically. These cells subvert the normal interactions between proteins which pass signals from outside the cell to the inside, to control cell behaviour and assume a survival advantage. We plan to study a form of cell signalling that is often abnormal in cancer in order to identify technologies for limiting cancer growth and spread by interfering with these signals.

随着癌症从良性发展到更恶性的形式，癌细胞对外部影响的反应方式发生了巨大变化。这些细胞破坏了蛋白质之间的正常相互作用，这些蛋白质将信号从细胞外传递到细胞内，以控制细胞行为并获得生存优势。我们计划研究一种在癌症中经常异常的细胞信号传导形式，以确定通过干扰这些信号来限制癌症生长和扩散的技术。