Using miR-200 to find new therapeutic targets for neuroblastoma

使用 miR-200 寻找神经母细胞瘤的新治疗靶点

• 批准号: nhmrc : 1129353
• 负责人: A/Pr Michael Samuel
• 金额: $ 38.44万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/using-mir-200-targets-neuroblastoma/948391
• 关键词: Using; miR; 200; find; new

Neuroblastoma is one of the most common cancers in children. We have found that a genetic regulator, called microRNA, can limit the ability of neuroblastoma cells to invade surrounding tissues and metastasise. We aim use the microRNAs to find new therapeutic targets that may work in combination with existing treatments, reducing the short term toxicity and long term deleterious effects of current treatments.

神经母细胞瘤是儿童最常见的癌症之一。我们发现一种叫做microRNA的基因调节因子可以限制神经母细胞瘤细胞侵入周围组织和转移的能力。我们的目标是利用microrna寻找新的治疗靶点，这些靶点可能与现有的治疗方法联合工作，减少当前治疗的短期毒性和长期有害影响。