Mast cells are key negative regulators of skin tumourigenesis

澳大利亚人是在高风险的太阳诱发的皮肤癌和皮肤损伤所造成的有害紫外线（UV）-B射线在阳光下。我们的研究重点是了解皮肤肥大细胞如何作为人体天然防御的一部分，对抗由过量UVB暴露或表皮化学损伤引起的皮肤肿瘤。了解防止过度皮肤损伤和癌症的先天机制可能会导致未来更好的预防和治疗策略。

Australians are at high risk of sun-induced skin cancer and skin damage caused by the harmful ultraviolet (UV)-B rays in sunlight. Our research focuses on understanding how skin mast cells act as part of the body’s natural defence against skin tumourigenesis caused by excessive UVB exposure or chemical insult to the epidermis. Understanding the innate mechanisms that protect against excessive skin damage and cancer might lead to better prevention and treatment strategies in the future.