权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

HIGH-RESOLUTION HIGH-MASS, TANDEM MASS SPECTROMETER

高分辨率、高质量串联质谱仪

基本信息

批准号：
3520975
负责人：
JEANETTE A MCNEILL
金额：
$ 40万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1991
资助国家：
美国
起止时间：
1991-07-16 至 1992-07-15
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3520975
关键词：
biomedical equipment purchase mass spectrometry

项目摘要

Funds are requested for the purchase of a high-mass, high-resolution tandem mass spectrometer. The mass spectrometer will be a modified version of a commercially available BEQQ instrument. The modifications include an octapole (o) instead of a quadrupole (q), features for perfomting photodissociation experiments, and features for perfomiing fundamental studies in the gas-phase chemistry of large biomolecular ions. The instrument will be housed in the Chemistiy Department in the interest of eff-icient operation and maintenance of the instrument. The current research of eleven NIH-funded investigators will be enhanced by this instrument. Furthermore, six other NIH-funded investigators have expressed a strong interest in the use of the instrumentation in five years. An association with the Emory Nhcrochemistry Center, originally funded by NIK also may provide an indirect use of the instrument to researchers outside the University community. Researchers who will use the proposed instrument are all performing biomedical-oriented research in diverse fields that require structure elucidation of neuropeptides in CNS, phosphoseryl peptides, bioactive peptide hormones, unknown sphingoid bases, phospholipids, uremic growth inhibitors, enzymes involved in neurohormone synthesis, flavoenzymes, and the anion exchange membrane protein band 3. Others are involved in studying the metabolism of glutathione, effects of ionizing radiation on DNA, and the structure and function of the enzyme myeloperoxidase. Other research involves investigating intrinsic interactions between metal ions and biological ligands, interactions between drugs and proteins and between host and guest molecules, energetics of fragmentations of biomolecular ions, and the fundamental photochemistry that is associated with the acdon of some anti-AIDS compounds. The proposed instrument is essential to the goals of these research projects.

要求提供资金，用于购买一台高质量、高分辨率的串联质谱仪质谱仪将是一种改良的市售BEQQ仪器的版本。的修改包括八极（O）而不是四极（Q），特征在于进行光解离实验，以及进行生物大分子气相化学基础研究离子。仪器将存放在化学部，仪器的有效操作和维护的兴趣。 11名NIH资助的研究人员目前的研究将得到加强通过这个工具。此外，其他六名NIH资助的研究人员已经表达了强烈的兴趣，在使用的仪器，五年埃默里化学中心的一个协会，最初由NIK资助的也可以提供间接使用大学社区以外的研究人员的工具。将使用拟议仪器的研究人员都在执行生物医学为导向的研究，在不同的领域，需要结构中枢神经系统中神经肽的阐明，磷酸丝氨酰肽，生物活性肽激素，未知鞘氨醇碱，磷脂，尿毒症生长抑制剂，参与神经激素合成的酶，黄素酶，和阴离子交换膜蛋白带3。其他人参与了研究谷胱甘肽的代谢，电离辐射对 DNA，以及髓过氧化物酶的结构和功能。其他研究涉及调查之间的内在相互作用金属离子和生物配体，药物之间的相互作用，蛋白质和主客体分子之间，生物分子离子的碎裂，以及基本的光化学与某些抗艾滋病化合物的作用有关。的拟议的工具是必不可少的目标，这些研究项目