PURCHASE OF 500 MHZ NMR SPECTROMETER

购买 500 MHZ 核磁共振波谱仪

• 批准号: 3520998
• 负责人: Frank M. Raushel
• 金额: $ 40万
• 依托单位: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-04-19 至 1992-04-18
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3520998
• 关键词: antiAIDS agent; biomedical equipment purchase; biomedical equipment resource; biomedical facility; drug design /synthesis /production; enzyme inhibitors; enzyme mechanism; enzyme substrate; free radicals; nuclear magnetic resonance spectroscopy; pharmacokinetics; porphyrin biosynthesis; protein folding

The primary objective of this proposal is to obtain a 500 MHz nuclear magnetic resonance spectrometer for five research groups within the Departments of Chemistry and Biochemistry at Texas A&M University. The instrument shall be utilized to solve structural and mechanistic problems involving PHS supported biomedical research. The Scott laboratory is addressing the structural intermediates in the biosynthesis of chlorophyll, vitamin-B12, penicillin and related molecules. The Pace laboratory is pursuing structural intermediates in protein folding using ribonuclease T1 as a model system. Reaction intermediates and dynamics of the reaction catalyzed by carbamoyl phosphate synthetase, phosphotriesterase, and bacterial luciferase are being probed by the Raushel laboratory. The Barton group is using high field NMR spectroscopy to determine the complex structures constructed in their organic synthesis program. The structures of novel amino acid and peptide mimics from controlled radical reactions are being investigated by the Newcomb laboratory.

该提案的主要目标是获得一个500兆赫的核 磁共振光谱仪的五个研究小组内， 德克萨斯A&M大学化学系和生物化学系。 的 应利用仪器解决结构和机械问题 涉及PHS的问题支持生物医学研究。 斯科特 实验室正在解决的结构中间体在 叶绿素、维生素B12、青霉素及相关 分子。 佩斯实验室正在寻找结构中间体， 使用核糖核酸酶T1作为模型系统的蛋白质折叠。 反应 氨基甲酰基催化反应的中间体及动力学 磷酸合成酶、磷酸三酯酶和细菌荧光素酶是 正在被劳舍尔实验室探测 巴顿集团正在使用高 场核磁共振光谱，以确定复杂的结构， 在有机合成项目中。 新氨基酸的结构 通过可控自由基反应得到的肽模拟物 由纽科姆实验室进行研究。