Defining a novel mechanism of control of host functions by human cytomegalovirus that enhances viral pathogenesis

定义人类巨细胞病毒控制宿主功能的新机制，增强病毒发病机制

• 批准号: nhmrc : 1063738
• 负责人: A/Pr Allison Abendroth
• 金额: $ 41.11万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/defining-novel-mechanism-viral-pathogenesis/455078
• 关键词: Defining; novel; mechanism; control; host

Human cytomegalovirus (HCMV) remains a significant human pathogen which causes serious and often life-threatening disease in immunosuppressed people such as bone marrow and solid organ transplant patients and in unborn babies infected during pregnancy. This project will define how HCMV controls host defences by actively modifying the cells it infects to create an environment favourable to continued viral infection and disease.

人类巨细胞病毒(HCMV)仍然是一种重要的人类病原体，它会在免疫抑制的人，如骨髓和实体器官移植患者，以及在怀孕期间感染的未出生婴儿中引起严重的、往往危及生命的疾病。该项目将确定HCMV如何通过积极修改其感染的细胞来控制宿主防御，以创造有利于继续病毒感染和疾病的环境。