Human cytomegalovirus encoded control of the latent phase of infection

人类巨细胞病毒编码感染潜伏期的控制

• 批准号: nhmrc : 1006199
• 负责人: A/Pr Allison Abendroth
• 金额: $ 42.67万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/human-cytomegalovirus-encoded-phase-infection/109153
• 关键词: Human; cytomegalovirus; encoded; control; latent

Human cytomegalovirus has the ability to hide in the body of a person throughout their life time without it making them ill but the virus can awaken (reactivate) from this latent state and produce new virus. In immunosuppressed people such as transplant patients this reactivation causes significant problems, even death, yet this latency remains poorly understood. This project will help us to understand how the virus can hide successfully from the immune system in a latent form in the human host.

人类巨细胞病毒有能力隐藏在一个人的身体在他们的一生中没有它使他们生病，但病毒可以唤醒（重新激活）从这种潜伏状态，并产生新的病毒。在免疫抑制的人群中，如移植患者，这种重新激活会导致严重的问题，甚至死亡，但这种潜伏期仍然知之甚少。该项目将帮助我们了解病毒如何以潜伏形式成功地隐藏在人类宿主的免疫系统中。