Mechanisms by which varicella zoster virus and herpes simplex virus control host functions to enhance pathogenesis

水痘带状疱疹病毒和单纯疱疹病毒控制宿主功能增强发病机制

• 批准号: nhmrc : 1088005
• 负责人: A/Pr Allison Abendroth
• 金额: $ 42.14万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanisms-varicella-zoster-enhance-pathogenesis/519192
• 关键词: Mechanisms; varicella; zoster; virus; herpes

Varicella Zoster Virus and Herpes Simplex Virus are alpha-herpesviruses that cause diseases in a majority of the human population. This proposal will explore issues fundamental to disease and pathogenesis of these two closely related herpesviruses, focusing on how these viruses can control host function. In particular, we will define the interactions between these viruses and the natural killer (NK) cell response.

水痘带状疱疹病毒和单纯疱疹病毒是在大多数人群中引起疾病的α-疱疹病毒。该提案将探讨这两种密切相关的疱疹病毒的疾病和发病机制的基本问题，重点是这些病毒如何控制宿主功能。特别是，我们将定义这些病毒和自然杀伤（NK）细胞反应之间的相互作用。