CHARACTERIZ. STEROID HORM. CONCENTR. NEURONS BY THEIR AXONAL PROJECTIONS

特点。

• 批准号: 3877645
• 负责人: JUANI MORRELL
• 金额: --
• 依托单位: RUTGERS THE STATE UNIV OF NJ NEWARK
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3877645
• 关键词: androgens; autoradiography; axon; estradiol; hormone regulation /control mechanism; hypothalamic hormones; limbic system; medulla oblongata; mesencephalon; progesterone; spinal cord; steroid hormone

Many gonadal-steroid dependent neuroendocrine events and behaviors are thought to be mediated by steroid hormones acting through preoptic, hypothalamic and limbic system neurons which contain steroid-specific receptor proteins. The experiments in this proposal are designed to reveal, on a cell-by-cell basis the extrahypothalamic axonal connections of gonadal steroid hormone-concentrating neurons by using steroid autoradiography combined with retrograde neuroanatomical tracing. These experiments will reveal exactly how steroid-concentrating neurons fit in neuroendocrinologically or behaviorally relevant neural circuits. These experiments will examine the axonal projections of estradiol-concentrating neurons to the medulla and spinal cord. These experiments will also examine the axonal projections of androgen- and of progesterone-concentrating neurons to the mesencephalon, or medulla or spinal cord. The long term goal of all these experiments is to reveal, on a neuron-by-neuron basis, the neuroanatomical circuitry of gonadal steroid hormone- concentrating neurons in order to uncover mechanisms by which steroid hormones exert their powerful effects on the brain.

许多性腺类固醇依赖性神经内分泌事件， 行为被认为是由类固醇激素介导的， 通过视前区、下丘脑和边缘系统神经元， 含有类固醇特异性受体蛋白。 中的实验 该提案旨在逐个细胞地揭示 下丘脑外性腺类固醇轴突联系 应用类固醇放射自显影技术研究神经元的聚集 结合逆行神经解剖追踪。 这些 实验将揭示浓缩类固醇 神经元与神经内分泌或行为相关 神经回路 这些实验将检查神经元的轴突投射， 雌激素集中神经元到髓质和脊髓。 这些实验还将检查神经元的轴突投射， 雄激素和胆甾酮集中神经元到 中脑或髓质或脊髓。 的长期目标 所有这些实验都是在一个神经元接一个神经元的基础上揭示， 性腺类固醇激素的神经解剖学回路 集中神经元，以揭示机制， 类固醇激素对大脑有很强的作用。