CHEMICAL ANTIDEPRESSANT EFFECTS ON BODY MASS AND BODY COMPOSITION IN HAMSTERS

化学抗抑郁药对仓鼠体重和身体成分的影响

• 批准号: 3880933
• 负责人: W C DUNCAN
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3880933
• 关键词: MAO inhibitors; anorexic agent; antidepressants; bioenergetics; bioperiodicity; body composition; body temperature; body temperature regulation; body weight; caloric dietary content; circadian rhythms; clinical depression; drug adverse effect; ethology; hamsters; hypothalamus; lipids; nonvisual photosensitivity; nutrient intake activity; nutrition related tag; oxygen consumption; psychobiology; psychopharmacology

Antidepressant drugs are reported to decrease in the resting metabolic rate and alter body mass of depressed patients. Increased body mass may be partly related to the decrease in metabolic rate. The change in energy budgeting that follows chronic drug treatment may be related to the behavior activating effects of antidepressant drugs. Chronic inhibition of type A monoamine oxidase (MAO) with the antidepressant drug clorgyline alters body mass in Syrian hamsters. This change in body mass was primarily due to an decrease in body lipid content. In the current studies we observed that the clorgyline decreases oxygen consumption the level of body temperature and food consumption in Syrian hamsters. Our working hypothesis is that the clorgyline-induced decrease in oxygen consumption and temperature are related to the diminished food intake that accompanies chronic drug administration. Our data are consistent with the interpretation that MAO inhibition decreases the temperature set-point of the hypothalamus.

据报道，抗抑郁药可降低静息代谢率 改变抑郁症患者的体重。体重增加可能是 部分与代谢率下降有关。的能量变化 慢性药物治疗后的预算可能与 抗抑郁药物的行为激活作用。 A型单胺氧化酶（MAO）的慢性抑制作用 抗抑郁药氯吉林改变了叙利亚仓鼠的体重。这 体重的变化主要是由于体内脂质含量的降低。 在目前的研究中，我们观察到氯吉林减少了氧气 叙利亚的体温和食物消费水平 仓鼠我们的工作假设是氯吉林诱导的 耗氧量和温度与减少的食物有关 伴随慢性药物给药的摄入量。我们的数据是 这与MAO抑制降低细胞增殖的解释一致。 下丘脑的温度设定点。