CHEMICAL ANTIDEPRESSANT EFFECTS ON BODY MASS AND BODY COMPOSITION IN HAMSTERS

化学抗抑郁药对仓鼠体重和身体成分的影响

• 批准号: 3859922
• 负责人: W C DUNCAN
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3859922
• 关键词: MAO inhibitors; antidepressants; bioenergetics; body composition; body temperature regulation; body weight; brain; brown fat; clinical depression; cortisol; hamsters; hormone regulation /control mechanism; hypothalamus; lipids; melatonin; oxygen consumption; prolactin; psychobiology; psychopharmacology

Antidepressant drugs are reported to decrease metabolic rate and alter body mass of depressed patients. Increased body mass may be partly related to the decrease in metabolic rate. The change in energy budgeting that follows chronic drug treatment may be related to the behavior activating effects of antidepressant drugs. Previously we have found that chronic inhibition of type A monoamine oxidase (MAO) with the antidepressant drug clorgyline a) alters body mass, b) decreases body lipid content, c) decreases oxygen and food consumption, and d) decreases the level of peritoneal and brain temperature in Syrian hamsters. Studies conducted in the past year have indicated that clorgyline treatment alters adrenal, kidney and testicular masses suggesting possible endocrine effects of clorgyline-treatment. Preliminary data collected in hamsters indicates that clorgyline treatment activates brown adipose tissue thermogenesis primarily during the active phase of the daily activity-rest cycle. This increased thermogenesis is possibly related to decreased body lipid content in chronically treated animals. Based on the observations that clorgyline decreases hypothalamic temperature and oxygen consumption, we have hypothesized that MAO inhibition decreases the thermoregulatory set-point of the hypothalamus. To further test this hypothesis, we have initiated a collaborative study with Dr. Christopher Gordon to evaluate the temperature preference of clorgyline-treated hamsters living on a temperature gradient. In sum, these studies are providing valuable information regarding alterations in daily energy budgeting following antidepressant drug treatment, and promise to be fruitful areas of investigation.

据报道，抗抑郁药可降低代谢率， 大量的抑郁症患者。 体重增加可能部分与 新陈代谢率的降低。 能源预算的变化， 慢性药物治疗可能与行为激活有关 抗抑郁药物的作用。 以前我们已经发现，A型单胺的慢性抑制 氧化酶（MAO）与抗抑郁药氯吉林a）改变体重， B）降低体内脂质含量，c）降低氧和食物消耗， 和d）降低叙利亚人的腹膜和脑温度水平 仓鼠 过去一年进行的研究表明， 氯吉林治疗改变肾上腺、肾脏和睾丸肿块 提示氯吉林治疗可能的内分泌效应。 初步 在仓鼠中收集的数据表明氯吉林治疗激活了 棕色脂肪组织产热主要是在活动期， 每日活动-休息周期 这种增加的产热可能是 与长期给药动物体内脂质含量降低相关。 基于氯吉林降低下丘脑 温度和氧气消耗，我们假设， 抑制降低了下丘脑的温度调节设定点。 为了进一步验证这一假设，我们发起了一项合作研究 与克里斯托弗·戈登博士一起评估了 氯吉林处理的仓鼠生活在温度梯度。 总的来说， 这些研究提供了关于 抗抑郁药物治疗后的每日能量预算， 成为富有成效的调查领域。