CHEMICAL ANTIDEPRESSANT EFFECTS ON BODY MASS AND BODY COMPOSITIION IN HAMSTERS

化学抗抑郁药对仓鼠体重和身体成分的影响

• 批准号: 3944832
• 负责人: W C DUNCAN
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3944832
• 关键词: MAO inhibitors; anorexic agent; antidepressants; basal metabolism; bioperiodicity; body composition; body weight; circadian rhythms; lipids; nutrient intake activity; nutrition related tag

In humans, one of the side effects of chronic chemical antidepressant treatment is a change in body mass. The mechanism of these induced changes is not clear but may include alterations in metabolic rate, as well as effects on specific body components such as body lipid, protein or water. We have previously noted chemical antidepressant induced alterations in the body mass of Syrian hamsters being treated chronically with the monoamine oxidase inhibitor (MAOI) clorgyline. This project was undertaken to more formally explore the behavioral and physiological mechanisms responsible for these alterations in Syrian hamsters. We have observed that initial clorgyline treatment decreases food intake. During chronic drug administration, clorgyline administration reduces the rate of weight gain although the level of food intake is not different from control. Thus, drug treated hamsters consume more food per unit of body mass than do control animals, i.e., they exhibit a negative energy balance relative to control animals. Analysis of the carcass composition of clorgyline treated hamsters indicates that drug induced changes are due to a decrease in body lipid content, rather than protein or water. SINCE seasonal changes in body mass are due to fluctuations in body lipid content, our results indicate that clorgyline may be affecting the same photoperiodic process which is responsible for photoperiodic-induced changes in body mass in the Syrian hamster.

对人类来说，慢性化学物质的副作用之一 抗抑郁治疗是改变体重。 的 这些诱导变化的机制尚不清楚，但可能包括 代谢率的改变，以及对特定身体的影响 例如身体脂质、蛋白质或水。 我们有 先前注意到的化学抗抑郁药诱导的改变， 叙利亚仓鼠的体重长期被治疗， 单胺氧化酶抑制剂（MAOI）氯吉林。 这个项目 进行了更正式的探索行为和 负责这些变化的生理机制， 叙利亚仓鼠。 我们已经观察到初始氯吉兰治疗减少了食物摄入， 摄入 在长期给药期间，氯吉林 给药降低了体重增加的速率， 与对照组没有什么不同。 因此，药物治疗 仓鼠每单位体重消耗的食物比 对照动物，即，它们表现出负能量平衡 相对于对照动物。 氯吉林处理猪胴体组成分析 仓鼠表明，药物诱导的变化是由于 减少体内脂质含量，而不是蛋白质或水。 由于身体质量的季节性变化是由于 身体脂质含量，我们的结果表明，氯吉林可能是 影响着同一个光周期过程 在叙利亚的光诱导的体重变化 仓鼠。