EFFECTS OF CHEMICAL ANTIDEPRESSANTS ON BODY MASS/BODY COMPOSITION IN HAMSTERS

据报道，抗抑郁药物可以降低静息代谢率。 增加抑郁症患者的体质量。体重增加可能是 部分与代谢率下降有关。能量的变化 慢性抗抑郁药物治疗后的预算可能与 药物的行为激活作用。这个项目调查了 改变的功能(如体温调节)和内分泌方面 身体质量。 此前我们发现慢性抑制A型单胺氧化酶 (MAO)在叙利亚仓鼠中使用抗抑郁药物clorgyline a) 防止正常体重增加，b)降低身体脂肪含量，c)， 减少氧气和食物消耗，以及d)降低 腹膜和大脑温度。我们还发现慢性Clorgyline 治疗改变肾上腺、肾脏、睾丸和棕色脂肪组织(BAT) 肿块，提示氯盖林治疗可能对 内分泌效应。根据这些器官数据，以及关于 褪黑素和皮质类固醇影响体温调节，我们研究了 老年人皮质醇、皮质酮、促肾上腺皮质激素和褪黑素的日变化 用Clorgyline治疗仓鼠以评估它们作为调解人的可能角色 Clorgyline对体温调节的影响。慢性环磷酰胺 治疗可提高松果体褪黑激素、血清ACTH、皮质醇和 皮质酮。慢性氯吉林降低糖尿病大鼠血压的观察 BAT的质量和升高的皮质类固醇水平与 有报道称，长期服用皮质酮会降低功能性 英美烟草公司的活动(GDP约束性)。相比之下，尽管褪黑素是 据报道，激活蝙蝠产热，提高褪黑素水平是 与蝙蝠质量的增加无关。因此，在叙利亚仓鼠中， MAOI clorgyline的慢性抗抑郁药物治疗可能会改变 皮质类固醇介导的抑制非寒战的体温调节 生热作用(NST)。 在与克里斯托弗·戈登博士的合作中，我们探索了 Clorgyline在体温调节的自主神经和行为方面的作用 叙利亚仓鼠。在寒冷的环境温度下，Clorgyline升高 代谢率和运动活动，可能是为了弥补 绝缘性体脂和/或减少的NST。当放置在加热的 梯度24小时后，氯吉林处理的仓鼠倾向于选择 较凉爽的环境温度和温度的昼夜节律 通常情况下出现的偏好并不存在。药物处理过的仓鼠 在温跃层的中温部分花费的时间也更少， 这表明这些动物的体温调节能力不那么强。 而不是控制动物。

Antidepressant drugs are reported to decrease the resting metabolic rate and increase body mass of depressed patients. Increased body mass may be partly related to the decrease in metabolic rate. The change in energy budgeting that follows chronic antidepressant treatment may be related to the behavior-activating effects of the drugs. This project investigates the functional ( e.g. thermoregulatory) and endocrine aspects of altered body mass. Previously we found that chronic inhibition of type A monoamine oxidase (MAO) in Syrian hamsters with the antidepressant drug clorgyline a) prevents normal weight gain, b) decreases body lipid content, c), decreases oxygen and food consumption, and d) decreases the level of peritoneal and brain temperature. We also found that chronic clorgyline treatment alters adrenal, kidney, testis and brown adipose tissue (BAT) masses, suggesting that clorgyline-treatment might have significant endocrine effects. In light of these organ data, as well as reports that melatonin and corticosteroids affect thermoregulation, we examined the daily variation of cortisol corticosterone, ACTH and melatonin in clorgyline-treated hamsters to assess their possible roles as mediators of clorgyline's effects on thermoregulation . Chronic clorgyline treatment was found to elevate pineal melatonin, serum ACTH, cortisol and corticosterone. The observation that chronic clorgyline decreases the mass of BAT and elevates levels of corticosteroids is consistent with reports that chronic corticosterone administration decreases functional activity (GDP binding) of BAT. In contrast, although melatonin is reported to activate BAT thermogenesis, elevation of melatonin levels was not associated with increased BAT mass. Thus, in Syrian hamsters, chronic antidepressant drug treatment with the MAOI clorgyline may alter thermoregulation by corticosteroid-mediated inhibition of non-shivering thermogenesis (NST). In collaboration with Dr. Christopher Gordon, we explored effects of clorgyline on autonomic and behavioral aspects of thermoregulation in Syrian hamsters. At cold ambient temperatures, clorgyline elevated metabolic rate and motor activity, possibly to compensate for the loss of insulative body fat and/or diminished NST. When placed on a thermal gradient for 24 hours, clorgyline-treated hamsters tended to select cooler ambient temperatures, and the circadian rhythm in thermal preference that is normally present was absent. Drug-treated hamsters also spent less time in the thermoneutral portion of the thermocline, suggesting that these animals' capacity to thermoregulate was less finely tuned than control animals.