HUMAN POPULATION GENETICS

人类群体遗传学

• 批准号: 3270024
• 负责人: LUIGI L CAVALLI-SFORZA
• 金额: $ 40.13万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1976
• 资助国家: 美国
• 起止时间: 1976-06-01 至 1991-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3270024
• 关键词: African; Asians; Jewish; Taiwan; agriculture; alleles; autoradiography; binding proteins; biochemical evolution; biological polymorphism; culture; ethnic group; evolution; fibroblasts; field study; gel electrophoresis; gene frequency; genetic disorder; genetic manipulation; genetic mapping; genetic markers; genetic registry /resource /referral center; geographic site; human migration; human population genetics; human population growth; leukocytes; linkage mapping; mathematical model; natural selections; nucleic acid sequence; radiotracer; restriction endonucleases; social change; sociolinguistics; sociology /anthropology; statistics /biometry; tissue /organ preservation

1. Theoretical modelling of population structure, and its cultural correlates as well as its effects on gene frequency variation in space and time. 2. Numerical data analysis: a) genes. We have set up a bank of gene frequency data, which is at the basis of an atlas of human variation to be published soon. Analysing the data of the bank will continue for substantial time. We are also interested in keeping the bank up to date for our analysis and for preparing successive editions of the atlas. b) Surnames. We have started analyzing with usual and new methods of population genetics data on surnames, and shown that this material is extremely interesting from the point of view of population genetics. We have two important sources of data: in Italy, consanguineous marriages since 1905, telephone books and electricity bills; in China, where surnames have been in existence for over 2000 years, we have started collecting a population sample and have a more ambitious program in sight for use of historical material. 3. Immortalization of a selected list of human populations which have evolutionary interest, and study of their DNA polymorphisms with restriction enzymes for a selected set of probes. 4. The collection of new data, and the use of available data bearing on the interaction of genes and culture, e.g. in determining artistic skills or epidemics of viral diseases. This is a highly varied list of problems, for many of which we often use a multiple strategy of attack. It would be impossible to conduct all these projects at a substantial pace with the requested financing. We plan to use this grant as a catalyzer, allowing some of the aims to start and fuel modestly, but keeping alive these ideas while additional money can be found to carry out specific aims.

1.人口结构的理论模型及其文化 及其对基因频率在空间和空间上的变异的影响 时间到了。 2.数值数据分析：a)基因。我们已经建立了一个基因库 频率数据，这是人类变异地图集的基础， 很快就会出版。分析银行的数据将继续进行 相当长的时间。我们也有兴趣使银行保持最新状态 供我们分析和编写地图集的后续版本。 B)姓氏。我们已经开始用通常的和新的方法来分析 关于姓氏的人口遗传学数据，并表明这种材料是 从种群遗传学的角度来看非常有趣。我们 有两个重要的数据来源：在意大利，近亲婚姻 自1905年以来，电话簿和电费；在中国，哪里姓 已经存在了2000多年，我们已经开始收集 人口样本，并有一个更雄心勃勃的计划在视线中使用 史料。 3.使一份选定的人口名单永垂不朽 进化兴趣及其DNA多态的研究 一组选定的探针的限制性内切酶。 4.收集新的数据，并使用与 基因和文化的相互作用，例如在确定艺术技能或 病毒性疾病的流行。 这是一个非常多样化的问题列表，对于其中的许多问题，我们经常使用 多种进攻策略。要做到这一切是不可能的 与所要求的资金同步进行的项目。我们计划 利用这笔拨款作为催化剂，允许一些目标启动和补充燃料 谦虚，但在能找到更多钱的情况下保持这些想法的活力 实现特定的目标。