HUMAN POPULATION GENETICS

人类群体遗传学

• 批准号: 3270026
• 负责人: LUIGI L CAVALLI-SFORZA
• 金额: $ 42.67万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1976
• 资助国家: 美国
• 起止时间: 1976-06-01 至 1991-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3270026
• 关键词: African; Asians; Jewish; Taiwan; agriculture; alleles; autoradiography; binding proteins; biochemical evolution; biological polymorphism; culture; ethnic group; evolution; fibroblasts; field study; gel electrophoresis; gene frequency; genetic disorder; genetic manipulation; genetic mapping; genetic markers; genetic registry /resource /referral center; geographic site; human migration; human population genetics; human population growth; leukocytes; linkage mapping; mathematical model; natural selections; nucleic acid sequence; radiotracer; restriction endonucleases; social change; sociolinguistics; sociology /anthropology; statistics /biometry; tissue /organ preservation

1. Theoretical modelling of population structure, and its cultural correlates as well as its effects on gene frequency variation in space and time. 2. Numerical data analysis: a) genes. We have set up a bank of gene frequency data, which is at the basis of an atlas of human variation to be published soon. Analysing the data of the bank will continue for substantial time. We are also interested in keeping the bank up to date for our analysis and for preparing successive editions of the atlas. b) Surnames. We have started analyzing with usual and new methods of population genetics data on surnames, and shown that this material is extremely interesting from the point of view of population genetics. We have two important sources of data: in Italy, consanguineous marriages since 1905, telephone books and electricity bills; in China, where surnames have been in existence for over 2000 years, we have started collecting a population sample and have a more ambitious program in sight for use of historical material. 3. Immortalization of a selected list of human populations which have evolutionary interest, and study of their DNA polymorphisms with restriction enzymes for a selected set of probes. 4. The collection of new data, and the use of available data bearing on the interaction of genes and culture, e.g. in determining artistic skills or epidemics of viral diseases. This is a highly varied list of problems, for many of which we often use a multiple strategy of attack. It would be impossible to conduct all these projects at a substantial pace with the requested financing. We plan to use this grant as a catalyzer, allowing some of the aims to start and fuel modestly, but keeping alive these ideas while additional money can be found to carry out specific aims.

1.人口结构的理论模型及其文化 以及它对空间基因频率变异的影响， 时间 2.数字数据分析：a）基因。 我们建立了一个基因库 频率数据，这是人类变异图谱的基础， 很快出版。 分析银行的数据将继续进行， 大量的时间。 我们也有兴趣让银行了解最新情况 用于我们的分析和准备地图集的后续版本。 B）姓氏。 我们已经开始用常规和新的方法进行分析， 人口遗传学数据的姓氏，并表明，这种材料是 从种群遗传学的角度来看，这是非常有趣的。 我们 我有两个重要的数据来源：在意大利，近亲结婚 自1905年以来，电话簿和电费;在中国， 已经存在了2000多年，我们已经开始收集 人口样本，并有一个更雄心勃勃的计划，在视线中使用 历史材料。 3.使一个选定的具有以下特征的人口名单永生化： 进化的兴趣，并研究他们的DNA多态性， 限制性内切酶用于选择的探针组。 4.新数据的收集和对现有数据的使用对 基因和文化的相互作用，例如在决定艺术技能或 病毒性疾病的流行。 这是一个非常多样化的问题列表，对于其中的许多问题，我们经常使用 多种攻击策略。 要进行所有这些是不可能的， 项目的进展速度与所要求的资金相当。 我们计划 利用这笔赠款作为催化剂，让一些目标开始和燃料 适度，但保持活力，这些想法，而额外的钱可以找到 实现具体目标。