GENERATION OF NEURONAL FORM AND FUNCTION

神经元形态和功能的生成

• 批准号: 3099528
• 负责人: JEFFREY L DENBURG
• 金额: $ 35.75万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 1979
• 资助国家: 美国
• 起止时间: 1979-07-01 至 1993-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3099528
• 关键词: developmental neurobiology; neurogenesis

Each proposal in this program project is concerned with cellular developmental neurobiology. The central hypothesis of these proposals is that there is a continuous interaction between the determinants of neuronal form and function, and that these interactions play an essential role in establishing the characteristics of the differentiated neuron. Although the basic analyses by these projects has been at the cellular level, there is an increased tendency to now carry these through to the molecular level. This is explicit in the application of hybridoma techniques by each of the projects. Some will use the monoclonal antibodies as labels for subsets of neurons to increase the resolution of the cellular analyses. Others will use the monoclonal antibodies to directly assist in the identification of molecules that are directly playing an important role in developmental processes. This shared interest in the cellular events occurring during the development of the nervous system and in the application of hybridoma techniques has resulted in many productive interactions and direct collaborations among all participants. Both invertebrate and vertebrate nervous systems are used in order to take advantage of specific properties of each. Those projects examining the factors controlling cell number by influencing rates of cell production or cell death will contribute to our understanding of degenerative disorders like Huntington's, Parkinson's and Alzheimer's diseases. The development of neuronal control of the endocrine system in cockroaches and identification of the neuropeptides involved will produce information useful in regulating excessive populations of insects. Some projects are studying axon growth - the effect of neuronal activity on it and the function and regulation of synthesis of molecules present in cells only during this process. Other projects study the specificity of synapse formation. Knowledge of the factors mediating axon growth and synapse formation obtained from these projects will be useful for developing more rational therapeutic treatments of neuronal damage from strokes, multiple sclerosis and direct injury.

本项目中的每一项提案都与蜂窝网络有关。 发育神经生物学 其中的核心假设是， 建议是，有一个持续的相互作用之间的 神经元的形式和功能的决定因素，这些 互动在建立 分化的神经元的特征。 虽然基本 这些项目的分析一直在细胞水平上， 越来越多的人倾向于把这些东西带到 分子水平。 这在杂交瘤的应用中是明确的 每个项目的技术。 有些人会用单克隆抗体 抗体作为神经元亚群的标记， 细胞分析的分辨率。 其他人将使用 单克隆抗体，以直接协助鉴定 直接发挥重要作用的分子 发展过程。 这种对细胞的共同兴趣 在神经系统发育过程中发生的事件 在杂交瘤技术的应用中， 许多富有成效的互动和直接合作， 参与者 无脊椎动物和脊椎动物的神经系统都用于 以便利用每种的特定属性。 那些 研究控制细胞数量的因素， 影响细胞产生或细胞死亡的速率将有助于 对我们理解像亨廷顿氏症这样的退化性疾病的影响， 帕金森氏症和老年痴呆症。 的发展 蟑螂内分泌系统的神经元控制， 对所涉及的神经肽的鉴定将产生 在控制昆虫数量过多方面有用的信息。 一些项目正在研究轴突生长-神经元的影响 活性及其合成的功能和调节 在这个过程中，细胞中只存在分子。 其他项目 研究突触形成的特异性。 知识 获得了介导轴突生长和突触形成的因子 从这些项目将有助于发展更合理的 中风引起的神经元损伤的治疗， 硬化和直接损伤。