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GENERATION OF NEURONAL FORM AND FUNCTION

神经元形态和功能的生成

基本信息

批准号：
3099530
负责人：
JEFFREY L DENBURG
金额：
$ 54.34万
依托单位：
UNIVERSITY OF IOWA
依托单位国家：
美国
项目类别：
财政年份：
1979
资助国家：
美国
起止时间：
1979-07-01 至 1994-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3099530
关键词：
developmental neurobiology neurogenesis

项目摘要

Each proposal in this program project is concerned with cellular developmental neurobiology. The central hypothesis of these proposals is that there is a continuous interaction between the determinants of neuronal form and function, and that these interactions play an essential role in establishing the characteristics of the differentiated neuron. Although the basic analyses by these projects has been at the cellular level, there is an increased tendency to now carry these through to the molecular level. This is explicit in the application of hybridoma techniques by each of the projects. Some will use the monoclonal antibodies as labels for subsets of neurons to increase the resolution of the cellular analyses. Others will use the monoclonal antibodies to directly assist in the identification of molecules that are directly playing an important role in developmental processes. This shared interest in the cellular events occurring during the development of the nervous system and in the application of hybridoma techniques has resulted in many productive interactions and direct collaborations among all participants. Both invertebrate and vertebrate nervous systems are used in order to take advantage of specific properties of each. Those projects examining the factors controlling cell number by influencing rates of cell production or cell death will contribute to our understanding of degenerative disorders like Huntington's, Parkinson's and Alzheimer's diseases. The development of neuronal control of the endocrine system in cockroaches and identification of the neuropeptides involved will produce information useful in regulating excessive populations of insects. Some projects are studying axon growth - the effect of neuronal activity on it and the function and regulation of synthesis of molecules present in cells only during this process. Other projects study the specificity of synapse formation. Knowledge of the factors mediating axon growth and synapse formation obtained from these projects will be useful for developing more rational therapeutic treatments of neuronal damage from strokes, multiple sclerosis and direct injury.

该计划项目中的每一项提案都与蜂窝发育神经生物学。其中的核心假设是建议是，在两个国家之间存在着持续的互动神经形态和功能的决定因素，这些互动在建立分化的神经元的特征。虽然基本的这些项目的分析一直在细胞层面上，有越来越多的人现在把这些带到分子水平。这一点在杂交瘤的应用中是显而易见的。每个项目的技术。有些人会使用单克隆性抗体作为神经元亚群的标记以增加细胞分析的分辨率。其他人将使用用于直接辅助鉴定的单抗直接扮演着重要角色的分子发育过程。这种对蜂窝网络的共同兴趣神经系统发育过程中发生的事件在杂交瘤技术的应用中导致了许多富有成效的互动和所有人的直接协作参与者。无脊椎动物和脊椎动物的神经系统都用于以便充分利用每种类型的特定属性。那些检查控制细胞数量的因素的项目影响细胞生产或细胞死亡的速度将有助于根据我们对亨廷顿氏症等退行性疾病的理解，帕金森氏症和阿尔茨海默病。的发展。蟑螂内分泌系统的神经元控制鉴定涉及的神经肽将产生对调节过多的昆虫种群有用的信息。一些项目正在研究轴突生长--神经元的影响它的活性及其合成的功能和调节分子只在这一过程中存在于细胞中。其他项目研究突触形成的特异性。了解以下内容获得调节轴突生长和突触形成的因素从这些项目中将有助于开发出更合理的多发性中风所致神经元损伤的治疗硬化症和直接损伤。