Defining the role of plasminogen activation in group A streptococcal invasive disease

“食肉”细菌A组链球菌(GAS)可导致致命的侵袭性疾病，如坏死性筋膜炎和中毒性休克综合症(每年60万例和163,000例死亡)。对于某些类型的气体，纤溶酶原结合对毒力是必不可少的。这项工作的目的是确定纤溶酶原结合在高毒力气体引起的疾病中的作用程度。这些研究将使开发新的疗法和治疗方法成为可能。

The "flesh-eating" bacteria group A streptococcus (GAS) causes life threatening invasive diseases such as necrotizing fasciitis and toxic shock syndrome (>600,000 cases and 163,000 deaths per year). For some types of GAS, plasminogen binding is essential for virulence.The aim of this work is to determine the extent to which plasminogen binding contributes to disease caused by highly virulent GAS. These studies will allow the development of new therapeutics and treatments.