Defining the role of plasminogen activation in group A streptococcal invasive disease

定义纤溶酶原激活在 A 组链球菌侵袭性疾病中的作用

• 批准号: nhmrc : 1009369
• 负责人: Dr Martina Sanderson-Smith
• 金额: $ 28.39万
• 依托单位: University of Wollongong
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/defining-role-plasminogen-invasive-disease/109403
• 关键词: Defining; role; plasminogen; activation; group

The "flesh-eating" bacteria group A streptococcus (GAS) causes life threatening invasive diseases such as necrotizing fasciitis and toxic shock syndrome (>600,000 cases and 163,000 deaths per year). For some types of GAS, plasminogen binding is essential for virulence.The aim of this work is to determine the extent to which plasminogen binding contributes to disease caused by highly virulent GAS. These studies will allow the development of new therapeutics and treatments.

“食肉”细菌 A 组链球菌 (GAS) 会导致危及生命的侵袭性疾病，例如坏死性筋膜炎和中毒性休克综合征（每年超过 600,000 例病例和 163,000 人死亡）。对于某些类型的 GAS，纤溶酶原结合对于毒力至关重要。这项工作的目的是确定纤溶酶原结合对高毒力 GAS 引起的疾病的影响程度。这些研究将有助于开发新的疗法和疗法。