Role of the host fibrinolytic system in invasive group A streptococcal disease

宿主纤溶系统在侵袭性 A 族链球菌疾病中的作用

• 批准号: nhmrc : 635218
• 负责人: Dr Martina Sanderson-Smith
• 金额: $ 35.44万
• 依托单位: University of Wollongong
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-host-fibrinolytic-streptococcal-disease/76625
• 关键词: Role; host; fibrinolytic; system; invasive

The flesh-eating bacterium group A streptococcus (GAS) is estimated to cause 700 million cases of self-limiting disease, and 600,000 cases of serious invasive disease each year. Approximately 25% of invasive infections are fatal. We have shown that GAS are able to hijack the host fibrinolytoc system to cause severe invasive infections. We plan to further examine the details of how this contributes to GAS disease. This research may contribute to the future devlopment of new therapeutics.

据估计，食肉细菌A组链球菌(GAS)每年导致7亿例自限性疾病和60万例严重侵袭性疾病。大约25%的侵袭性感染是致命的。我们已经证明，GAS能够劫持宿主的纤溶系统，导致严重的侵袭性感染。我们计划进一步研究这是如何导致气体疾病的细节。这一研究可能对未来新疗法的开发有所帮助。