Role of the host fibrinolytic system in invasive group A streptococcal disease

据估计，食肉细菌A群链球菌（GAS）每年导致7亿例自限性疾病和60万例严重侵袭性疾病。大约25%的侵袭性感染是致命的。我们已经证明，GAS能够劫持宿主纤维蛋白溶解系统，引起严重的侵袭性感染。我们计划进一步研究这如何导致GAS疾病的细节。这项研究可能有助于未来新疗法的发展。

The flesh-eating bacterium group A streptococcus (GAS) is estimated to cause 700 million cases of self-limiting disease, and 600,000 cases of serious invasive disease each year. Approximately 25% of invasive infections are fatal. We have shown that GAS are able to hijack the host fibrinolytoc system to cause severe invasive infections. We plan to further examine the details of how this contributes to GAS disease. This research may contribute to the future devlopment of new therapeutics.