Mechanisms of immune-evasion by Group A Streptococcus during skin infection

皮肤感染过程中 A 族链球菌的免疫逃避机制

• 批准号: nhmrc : GNT1085981
• 负责人: Dr Martina Sanderson-Smith
• 金额: $ 58.38万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanisms-immune-evasion-skin-infection/1345644
• 关键词: Mechanisms; immune; evasion; Group; Streptococcus

Infections by Group A Streptococcus (GAS), or Streptococcus pyogenes, represent a global health concern. Currently no vaccine exists against GAS thereby mandating a better understanding of the immune response against the bacterium. Using in vivo microscopy, the aim of this proposal is to dissect in real time how neutrophils detect and destroy GAS following skin infection, and how the bacterium manages to circumvent the attack by innate immune cells.

A组链球菌（GAS）或化脓性链球菌感染代表了全球健康问题。目前还没有针对GAS的疫苗，因此需要更好地了解针对该细菌的免疫反应。使用体内显微镜，该提案的目的是在真实的时间内剖析中性粒细胞如何在皮肤感染后检测和破坏GAS，以及细菌如何设法规避先天免疫细胞的攻击。