DIABETIC KIDNEY STUDY--ENALAPRIL IN TYPE II DIABETICS WITH HYPERTENSION

糖尿病肾脏研究——依那普利治疗患有高血压的 II 型糖尿病患者

• 批准号: 3887069
• 负责人: WARREN K BOLTON
• 金额: --
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3887069
• 关键词: ACE inhibitors; antihypertensive agents; clinical trials; diabetic nephropathy; enalapril; hemodynamics; human subject; human therapy evaluation; kidney circulation; kidney disorder chemotherapy; kidney disorder diagnosis; kidney function; noninsulin dependent diabetes mellitus; renal hypertension

Studies done in animals and in humans have suggested that the natural history of diabetic kidney disease can be altered by changing renal hemodynamics and function using enalapril. This study will test these hypotheses. Patients will be randomized to two groups in a double blinded study. These groups will consist of placebo/enalapril. Their kidney function will be monitored at six-month intervals measuring protein excretion, 24 hour creatine clearance, and iothalomate.

对动物和人类进行的研究表明，自然 糖尿病肾病史可以通过改变肾功能来改变 使用依那普利的血流动力学和功能。 本研究将测试这些 假设。 患者将在双盲试验中被随机分为两组 学习。 这些组将由安慰剂/依那普利组成。 他们的肾 将每隔六个月监测一次功能，测量蛋白质 排泄、24 小时肌酸清除率和碘酞酸盐。