ALDOSE REDUCTASE--ITS ROLE IN ETIOLOGY AND TREATEMENT OF DIABETIC NEUROPATHY

醛糖还原酶——其在糖尿病神经病的病因学和治疗中的作用

• 批准号: 3887359
• 负责人: ROBERT P EATON
• 金额: --
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3887359
• 关键词: aldehyde reductase; diabetes mellitus therapy; diabetic neuropathy; edema; enzyme induction /repression; genetic regulation; human subject; human therapy evaluation; medical complication; oxidoreductase inhibitor

The focus of this project is to examine the putative role of aldose reductase (AR) in the pathogenesis of diabetic complications. Specifically, we will look as aspects relative to etiology and treatment of diabetic neuropathy. With regards to etiology, we will evaluate AR activity relative to mRNA to examine genetic regulation and expression of this enzyme. By pharmacologically inhibiting the AR gene product, we hope to reverse nerve dysfunction manifested as endoneurial edema.

本项目的重点是检验醛糖的假定作用