INDUCTION OF POLYOL PATHWAY ENZYMES IN DIABETES MELLITUS

糖尿病中多元醇途径酶的诱导

• 批准号: 3887316
• 负责人: ROBERT P EATON
• 金额: --
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3887316
• 关键词: aldehyde reductase; connective tissue metabolism; diabetes mellitus; enzyme induction /repression; glucose metabolism; human subject; pathology; peripheral nervous system

The hypothesis is that patients with increased AR activity will generate increased polyol from glucose, and this increased influx alters cell and tissue function com[promising organ function. While we are targeting the peripheeral nerve, we also would apply the hypothesis to the kidney, the retina, and the heart, as well as connective tissue generally.

假设AR活性增加的患者会产生 增加的多元醇从葡萄糖，这种增加的流入改变细胞， 组织功能包括有希望的器官功能。当我们瞄准 如果是外周神经，我们也会将该假设应用于肾脏， 视网膜和心脏，以及一般的结缔组织。