INHIBITION OF ALDOSE REDUCTASE IN A SIX-MONTH TREATMENT OF ELEVATED SURAL NERVE

六个月的腓肠神经升高治疗中醛糖还原酶的抑制

• 批准号: 3787928
• 负责人: ROBERT P EATON
• 金额: --
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3787928
• 关键词: aldehyde reductase; biomarker; diabetic neuropathy; diagnosis design /evaluation; human subject; magnetic resonance imaging; nervous system disorder diagnosis; neuromuscular disorder chemotherapy; oxidoreductase inhibitor

This project is directed at testing the hypothesis that diabetic sural nerve water represents a marker for increased aldose reductase flux, as an early and reversible step in the pathogenesis of diabetic neuropathy. We plan to administer an inhibitor of AR, Tolrestst, in a double blind fashion to 20 diabetic subjects with elevated nerve water and early neuropathy, and to follow the nerve water and neuropathy with MRI and neurophysiology testing to determine both the validity of the hypothesis & utility of AR inhibition as a therapy.

该项目旨在验证糖尿病患者存活的假设