Lifetime musical experience and healthy ageing

终生的音乐体验和健康老龄化

• 批准号: ES/S015604/1
• 负责人: Judith Okely
• 金额: $ 29.97万
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=ES%2FS015604%2F1
• 关键词: Lifetime; musical; experience; healthy; ageing

From nursery rhymes to playing in a band or joining a choir in retirement, our lives are punctuated by music. These are life-enhancing experiences for many of us, but could making or listening to music also help us tackle challenges related to ageing? As a global population, we are aging rapidly. This trend brings many challenges, as people often suffer from poorer health and declining memory and thinking skills in older age. Listening to music and music making are unique mentally demanding tasks which involve the combination of different mental processes including attention, emotion, memory, and in the case of playing a musical instrument, physical coordination and skill. Findings from previous studies have documented the benefits of playing a musical instrument in terms of better cognitive or language development in children and improved performance on tests of cognitive function in adults. Neuroimaging studies of brain structure indicate that musical training is associated with certain brain differences. In addition, other studies have documented the psychological benefits of various forms of musical experience including playing an instrument, singing and listening to music. Less is known regarding the potential association between musical experience and outcomes in older age. In particular, it is unclear whether musical experience is related to changes in cognitive function, brain structure or psychological wellbeing in older age. The aim of the proposed project is to examine these potential associations. I will examine associations between musical experience and healthy ageing using data from the Lothian Birth Cohort study 1936 (LBC1936). Every three years, since the age of 70, LBC1936 participants have completed an extremely detailed battery of thinking and memory tests. Participants have had multiple brain MRI scans and provided extensive health, demographic, psychological and lifestyle data. Importantly, a measure of cognitive ability in childhood is also available for these participants. At the most recent wave of the study, at age 82, participants completed a lifetime musical experience questionnaire. The questionnaire provides a detailed retrospective account of lifetime musical instrument training and practice. It also assesses other aspects of lifetime musical experience including singing and music listening.Using these data, I will address the following unresolved questions: 1) what are the demographic, health, and childhood cognitive characteristics of people with high levels of lifetime musical experience? This work will help establish whether the association between musical experience and healthy ageing might be causal, or simply a by-product of another factor which influences both musical experience and ageing outcomes (e.g. socioeconomic status). 2) Is experience playing a musical instrument related to lifetime cognitive change? Cognitive function in childhood is one of the main predictors of cognitive function in older age, in this study I will test if people with more experience playing a musical instrument tend to have higher cognitive abilities at age 70 than would be expected given their cognitive ability at age 11. 3) Is experience playing a musical instrument related to level or change in cognitive ability or brain structure in older age? 4) Is experience playing a musical instrument, singing or music listening related to level or change in psychological wellbeing in older age? In testing these questions, I will statistically control for the factors, identified in the first study, which might account for associations between musical experience and cognitive, brain or psychological health in older age. My results could lay the groundwork for establishing whether musical experience - and experience playing a musical instrument in particular - is beneficial for older people.

从童谣到乐队演奏或退休后加入合唱团，我们的生活都被音乐打断。对我们许多人来说，这些都是提高生活质量的经历，但制作或听音乐是否也能帮助我们应对与衰老有关的挑战？作为全球人口，我们正在迅速老龄化。这一趋势带来了许多挑战，因为人们往往在老年时健康状况较差，记忆力和思维能力下降。听音乐和音乐制作是独特的脑力要求任务，涉及不同的心理过程的组合，包括注意力，情感，记忆，以及在演奏乐器的情况下，身体协调和技能。以前的研究结果已经证明了演奏乐器在儿童更好的认知或语言发展方面的好处，以及在成人认知功能测试中的表现。对大脑结构的神经影像学研究表明，音乐训练与某些大脑差异有关。此外，其他研究也记录了各种形式的音乐体验的心理益处，包括演奏乐器，唱歌和听音乐。关于音乐体验与老年人结果之间的潜在联系，人们知之甚少。特别是，目前还不清楚音乐体验是否与老年人认知功能，大脑结构或心理健康的变化有关。拟议项目的目的是审查这些潜在的关联。我将使用1936年洛锡安出生队列研究（LBC 1936）的数据来研究音乐体验与健康老龄化之间的关联。从70岁开始，每隔三年，LBC 1936的参与者都要完成一系列非常详细的思维和记忆测试。参与者进行了多次脑部MRI扫描，并提供了广泛的健康，人口统计学，心理和生活方式数据。重要的是，儿童时期的认知能力也可用于这些参与者。在最近一轮研究中，参与者在82岁时完成了一份终身音乐体验问卷。问卷提供了一个详细的回顾性帐户的终身乐器训练和实践。它还评估了一生中音乐体验的其他方面，包括唱歌和听音乐。使用这些数据，我将解决以下未解决的问题：1）具有高水平一生音乐体验的人的人口统计学，健康和儿童认知特征是什么？这项工作将有助于确定音乐体验和健康老龄化之间的关联是否可能是因果关系，或者仅仅是影响音乐体验和老龄化结果（例如社会经济地位）的另一个因素的副产品。2)演奏乐器的经历与终生认知变化有关吗？儿童时期的认知功能是老年认知功能的主要预测因素之一，在这项研究中，我将测试具有更多演奏乐器经验的人在70岁时的认知能力是否比11岁时的认知能力更高。3)演奏乐器的经验与老年人认知能力或大脑结构的水平或变化有关吗？4)演奏乐器、唱歌或听音乐的经历是否与老年人的心理健康水平或变化有关？在测试这些问题时，我将对第一项研究中确定的因素进行统计控制，这些因素可能会解释音乐体验与老年人认知，大脑或心理健康之间的联系。我的研究结果可以为确定音乐体验--尤其是演奏乐器的体验--是否对老年人有益奠定基础。

项目成果

sj-docx-1-pss-10.1177_09567976221092726 - Supplemental material for Experience of Playing a Musical Instrument and Lifetime Change in General Cognitive Ability: Evidence From the Lothian Birth Cohort 1936

sj-docx-1-pss-10.1177_09567976221092726 - 演奏乐器的经验和一般认知能力的终生变化的补充材料：来自 1936 年洛锡安出生队列的证据

• DOI: 10.25384/sage.20713227
• 发表时间: 2022
• 作者: Okely J

Predicting COVID-19 vaccine take-up: Moving beyond demographics.

• DOI: 10.1016/j.bbi.2021.03.021
• 发表时间: 2021-07
• 期刊: Brain, behavior, and immunity
• 作者: Batty GD;Deary IJ
• 通讯作者: Deary IJ

The Edinburgh Lifetime Musical Experience Questionnaire (ELMEQ): Responses and non-musical correlates in the Lothian Birth Cohort 1936.

• DOI: 10.1371/journal.pone.0254176
• 发表时间: 2021
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Okely JA;Deary IJ;Overy K
• 通讯作者: Overy K

Pre-pandemic cognitive function and COVID-19 mortality: prospective cohort study.

• DOI: 10.1007/s10654-021-00743-7
• 发表时间: 2021-05
• 期刊: European journal of epidemiology
• 影响因子: 13.6
• 作者: Batty GD;Deary IJ;Gale CR
• 通讯作者: Gale CR

Cerebral small vessel disease burden and longitudinal cognitive decline from age 73 to 82: the Lothian Birth Cohort 1936.

• DOI: 10.1038/s41398-021-01495-4
• 发表时间: 2021-07-06
• 期刊: Translational psychiatry
• 影响因子: 6.8
• 作者: Hamilton OKL;Cox SR;Okely JA;Conte F;Ballerini L;Bastin ME;Corley J;Taylor AM;Page D;Gow AJ;Muñoz Maniega S;Redmond P;Valdés-Hernández MDC;Wardlaw JM;Deary IJ
• 通讯作者: Deary IJ