Defining a virally-encoded molecular switch between productive and latent phases of human cytomegalovirus infection.

定义人类巨细胞病毒感染的生产期和潜伏期之间的病毒编码分子开关。

• 批准号: nhmrc : 1030707
• 负责人: A/Pr Barry Slobedman
• 金额: $ 22.51万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/defining-virally-encoded-cytomegalovirus-infection/110769
• 关键词: Defining; virally; encoded; molecular; switch

Human cytomegalovirus (HCMV) is a significant human pathogen which causes serious disease in immunosuppressed people such as bone marrow and solid organ transplant patients. HCMV has the capacity to switch between an active and a dormant state, enabling this virus to remain within the human host, where it can emerge years later to cause disease in immunosuppressed people. This project will define how HCMV controls the switch between active and dormant phases of infection.

人巨细胞病毒（HCMV）是一种重要的人类病原体，可在骨髓和实体器官移植患者等免疫抑制人群中引起严重疾病。HCMV具有在活跃状态和休眠状态之间切换的能力，使这种病毒能够留在人类宿主体内，多年后它可能在免疫抑制的人群中出现并引起疾病。该项目将定义HCMV如何控制感染活跃和休眠阶段之间的切换。