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ABCA1 _ an Intersection between Infection, Atherosclerosis and Metabolic Disorders

ABCA1 _ an Intersection between Infection, Atherosclerosis and Metabolic Disorders
ABCA1 _感染、动脉粥样硬化和代谢紊乱之间的交叉点
批准号：
nhmrc : 1019847
负责人：
A/Pr Barry Slobedman
金额：
$43.6万
依托单位：
Baker IDI Heart and Diabetes Institute
依托单位国家：
澳大利亚
项目类别：
Project Grants
财政年份：
2012
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2012-01-01 至 2014-12-31
来源：
https://researchdata.edu.au/abca1-an-intersection-metabolic-disorders/109985
关键词：
ABCA1IntersectionbetweenInfectionAtherosclerosis

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中文摘要
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英文摘要
Pathogens interfere with cellular cholesterol metabolism in order to support their lifecycle. Such interference may cause diseases not usually associated with infection, like cardiovascular disease. Restoring normal cholesterol metabolism may help treating infection and its metabolic consequences. We will investigate molecular, cellular and physiological mechanisms of interaction of pathogens with cholesterol metabolism to find a key point that can be targeted for therapeutic intervention.
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