How does human cytomegalovirus control host responses to infection to facilitate human disease?

人类巨细胞病毒如何控制宿主对感染的反应以促进人类疾病？

• 批准号: nhmrc : GNT1063738
• 负责人: A/Pr Barry Slobedman
• 金额: $ 39.76万
• 依托单位: University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/does-human-cytomegalovirus-human-disease/1344849
• 关键词: How; does; human; cytomegalovirus; control

Human cytomegalovirus (HCMV) remains a significant human pathogen which causes serious and often life-threatening disease in immunosuppressed people such as bone marrow and solid organ transplant patients and in unborn babies infected during pregnancy. This project will define how HCMV controls host defences by actively modifying the cells it infects to create an environment favourable to continued viral infection and disease.

人巨细胞病毒（HCMV）仍然是一种重要的人类病原体，其在免疫抑制的人如骨髓和实体器官移植患者以及在妊娠期间感染的未出生婴儿中引起严重且通常危及生命的疾病。该项目将定义HCMV如何通过主动修饰其感染的细胞来控制宿主防御，以创造有利于持续病毒感染和疾病的环境。